ВОЗМОЖНО ЛИ ВЛИЯНИЕ МИКОПЛАЗМЕННОЙ ИНФЕКЦИИ НА ПАТОГЕНЕЗ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ?
Аннотация
Objective: to define a possible correlation between Mycoplasma infection persistence and prostate cancer (PC). Subjects and methods. Two hundred and fifty males aged 45 to 83 years (mean age 65.50.71 years) with suspected PC were examined. In all the patients, polyfocal prostate biopsy from 12 points was carried out, by additionally taking 2 tissue columns from the peripheral area of both lobes. The basic material was referred for morphological study; the two additional columns were tested for Mycoplasma DNA by a polymerase chain reaction (PCR) and real-time PCR. The study was blind. According to the morphological findings, the patients were divided into 2 groups: 1) those with chronic prostatitis, prostate adenoma, low-grade prostatic interstitial neoplasia (PIN); 2) those with high-grade PIN (HG-PIN), PC. There were no age differences between the groups (p = 0.05). Results. The standard procedure for PCR was applied to 127 subjects. Twenty-six (20.5%) of the 127 subjects with suspected PC were found to have Mycoplasma infection, Mycoplasma being detected in 21 (26.2%) of the 81 patients with verified HG-PIN and PC. Mycoplasma hominis was encountered in 19 (15%) patients of the 127 subjects with suspected PC and this infection was present in 16 (20%) of the 81 patients with verified HG-PIN and PC. Comparison of the frequency of HG-PIN and PC in the patients of general group (60%) and in those with Mycoplasma infection (80.8%) revealed significant differences (p = 0.031). HG-PIN and PC were also significantly more frequently seen in the patients with Mycoplasma hominis (84.2%) that in the general patient group (60%) (p = 0.033). There were no significant differences in the frequency of HG-PIN and PC between the patients from the general group (60%) and those with Mycoplasma genitalium (71.4%) (p = 0.05). The patients with verified PC and HG-PIN were more frequently found to have Mycoplasma hominis (20%) than Mycoplasma genitalium (6.2%), which further drew our closer attention to just this pathogen. The real-time PCR was used in 123 subjects to detect Mycoplasma. HG-PIN and prostate adenocarcinoma were revealed in 63 of the 123 patients with suspected PC, Mycoplasma hominis was seen in 46 (37%). The frequency (n=46) was 73.9%. The frequency of HG-PIN and PC was significantly higher in the patients with isolated Mycoplasma hominis DNA that in those without this pathogen (p < 0.001). Conclusion. Thus, the investigation showed a significantly higher correlation in the frequency of HG-PIN and PC in the patients with Mycoplasma infection that in the general study patients with suspected PC. This was supported by the use of both the standard procedure for Mycoplasma DNA determination and real-time PCR diagnosis.
Об авторах
Ю. Г. Аляев
ММА им. И.М. Сеченова
Россия
Россия
А. З. Винаров
ММА им. И.М. Сеченова
Россия
Россия
Д. Н. Фиев
ММА им. И.М. Сеченова
Россия
Россия
Ю. А. Барыкова
НИИЭМ им. Н.Ф. Гамалеи РАМН, Москва
Россия
Россия
Н. А. Винарова
ММА им. И.М. Сеченова
Россия
Россия
Д. Ю. Логунов
НИИЭМ им. Н.Ф. Гамалеи РАМН, Москва
Россия
Россия
М. М. Шмаров
НИИЭМ им. Н.Ф. Гамалеи РАМН, Москва
Россия
Россия
Б. С. Народицкий
НИИЭМ им. Н.Ф. Гамалеи РАМН, Москва
Россия
Россия
А. В. Гудков
Институт рака, Росвэлл Парк, США
Россия
Россия
А. Л. Гинцбург
НИИЭМ им. Н.Ф. Гамалеи РАМН, Москва
Россия
Россия
Список литературы
1. Wagenlehner F.M., Elkahwaji J.E., Algaba F. et al. The role of inflammation and infection in the pathogenesis of prostate carcinoma. BJU Int 2007;100(4):733-7.
2. May M., Kalisch R., Hoschke B. et al. Detection of papillomavirus DNA in the prostate: a virus with underestimated clinical relevance? Urologe 2008;47(7):846-52.
3. Balis V., Sourvinos G., Soulitzis N. et al. Prevalence of BK virus and human papillomavirus in human prostate cancer. Int J Biol Markers. 2007;22(4):245-51.
4. Baron E.J., Peterson L.R., Finegold S.M. genital and sexually transmitted pathogens. In: Bailey and Scott's Diagnostic Microbiology. 9th ed.
5. C.V. Mosby Co., St. Louis, MO, 1994.
6. Waites K.B., Taylor-Robinson D. Mycoplasma and Ureaplasma, in manual of clinical microbiology. P.R. Murray et al., eds. American Society for Microbiology Press, 1999. p. 782-94.
7. Прилепская В.Н., Кисина В.И., Соколовский Е.В. К вопросу о роли микоплазм в урогенитальной патологии. Гинекология 2007;9(1):31-8.
8. Arya O.P., Tong C.Y., Hart C.A. et al. Is Mycoplasma hominis a vaginal pathogen? Sex Transm Infect 2001;77(1):58-62.
9. Бенькович А.С. Инфекции, вызываемые Mycoplasma genitalium: клинические проявления, особенности диагностики и терапии. Клин дерматол венерол 2008;3:61-2. 9. Sexually transmitted diseases treatment guidelines 2002. Centers for Disease Control and Prevention. MMWR Recomm Rep 2002;51(RR-6):1.
10. Taylor-Robinson D. Infections due to species of Mycoplasma and Ureaplasma: an update. Clin Infect Dis 1996;23:671.
11. Остроумов О.А. Влияние хламидийной и микоплазменной инфекции на развитие неблагоприятных исходов беременности. Акт вопр акуш гинекол 2001-2002;1(1).
12. Horowitz J., Horowitz S., Mazor M. et al. Ureaplasma urealyticum cervical colonization as a marker for pregnancy complications. Int J Gynaecol Obstet 1995;48:15-9.
13. Calleri L.F., Taccani C., Porcelli A. Ureaplasma urealyticum vaginosis and premature rupture of membranes. What is its role? Minerva Ginecol 2000;52:49-58.
14. Donders G.C., Van Bulck B., Caudron J. et al. Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion. Am J Obstet Gynecol 2000;183:431-7.
Для цитирования:
Аляев Ю.Г., Винаров А.З., Фиев Д.Н., Барыкова Ю.А., Винарова Н.А., Логунов Д.Ю., Шмаров М.М., Народицкий Б.С., Гудков А.В., Гинцбург А.Л. ВОЗМОЖНО ЛИ ВЛИЯНИЕ МИКОПЛАЗМЕННОЙ ИНФЕКЦИИ НА ПАТОГЕНЕЗ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ? Онкоурология. 2010;6(1):28-32. https://doi.org/10.17650/1726-9776-2010-6-1-28-32
For citation:
Alyaev Yu.G., Vinarov A.Z., Fiyev D.N., Barykova Yu.A., Vinarova N.A., Logunov D.Yu., Shmarov M.M., Naroditsky B.S., Gudkov A.V., Gintsburg A.L. CAN MYCOPLASMA INFECTION AFFECT THE PATHOGENESIS OF PROSTATE CANCER? Cancer Urology. 2010;6(1):28-32. (In Russ.) https://doi.org/10.17650/1726-9776-2010-6-1-28-32
Просмотров: 443
Послать статью по эл. почте 
