The validation results for APhiGT algorithm for clarification of prostate cancer staging before treatment (first step)

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Abstract

Background. We have previously described an algorithm APhiGT (Age, Prostate Health index, Gleason score, TNM stage) for staging of prostate cancer (PC) before treatment. The algorithm was developed by logistic regression on an educational selection (ES) of 337 PC cases. The algorithm includes data about the age of patients, the levels of total prostate-specific antigen (PSA), free PSA, [-2]proPSA and the ranked data of the Gleason score (by biopsy results) and T (by TNM).

Objective. Validation of APhiGT on the validation selection (VS) of 83 PC cases was carried out in this work.

Materials and methods. ROC analysis was performed in ES and VS.

Results and сonclusion. It is established that area under the curve (AUC), characterizing the ability to divide clinically significant subgroups of patients (Gleason score <7 vs. Gleason score ≥7, рТ2 vs. рТ3, localized indolent PC vs. localized aggressive PC) for APhiGT both in ES and VS was significantly higher than AUC for total PSA, %[-2]proPSA in free PSA and prostate health index. At the same time, in all clinical subgroups of patients AUC for VS was lower than AUC for ES, which may be due to a significantly smaller size of VS compared to ES.

About the authors

N. S. Sergeeva

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Author for correspondence.
Email: prognoz.06@mail.ru
ORCID iD: 0000-0001-7406-9973

3 2nd Botkinskiy Proezd, Moscow 125284, 

1 Ostrovityanovа St., Moscow 117997

Russian Federation

T. E. Skachkova

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: belaia_loshadka@mail.ru
ORCID iD: 0000-0002-1786-6244

3 2nd Botkinskiy Proezd, Moscow 125284

Russian Federation

N. V. Marshutina

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: prognoz.06@mail.ru
ORCID iD: 0000-0003-2997-4936

3 2nd Botkinskiy Proezd, Moscow 125284

Russian Federation

K. M. Nushko

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: kirandja@yandex.ru
ORCID iD: 0000-0002-4171-6211

3 2nd Botkinskiy Proezd, Moscow 125284

Russian Federation

I. M. Shevchuk

N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: imshevchuk@mail.ru
ORCID iD: 0000-0002-6877-0437

Build. 1, 51 3rd Parkovaya St., Moscow 105425

Russian Federation

M. R. Nazirov

N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: nazirov84@mail.ru
ORCID iD: 0000-0001-9720-9406

Build. 1, 51 3rd Parkovaya St., Moscow 105425

S. A. Pirogov

Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences

Email: s.a.pirogov@bk.ru
ORCID iD: 0000-0002-3522-2020

Build. 1, 19 Bol’shoy Karetnyy Pereulok, Moscow 127051

Russian Federation

E. F. Yurkov

Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences

Email: jork@iitp.ru
ORCID iD: 0000-0001-8932-560X

Build. 1, 19 Bol’shoy Karetnyy Pereulok, Moscow 127051

Russian Federation

V. G. Gitis

Institute for Information Transmission Problems (Kharkevich Institute), Russian Academy of Sciences

Email: gitis@iitp.ru
ORCID iD: 0000-0003-1123-6433

Build. 1, 19 Bol’shoy Karetnyy Pereulok, Moscow 127051

B. Ya. Alekseev

National Medical Research Radiological Center, Ministry of Health of Russia

Email: byalekseev@mail.ru
ORCID iD: 0000-0002-1353-2271

4 Koroleva St., Obninsk 249031

Russian Federation

A. D. Kaprin

National Medical Research Radiological Center, Ministry of Health of Russia

Email: kaprin@mail.ru
ORCID iD: 0000-0001-8784-8415

4 Koroleva St., Obninsk 249031

Russian Federation

References

  1. Sergeeva N.S., Skachkova T.E., Alekseev B.Ya. et al. APHIG: a new multiparameter index for prostate cancer. Onkourologiya = Cancer Urology 2016;12(4):89–95. (In Russ.). doi: 10.17650/1726-9776-2016-12-4-94103.
  2. Alekseev B., Skachkova T., Sergeeva N. et al. MP53-09 New algorithm APHIGT for prostate cancer staging. AUA 2018. The Moscone Center. San Francisco, CA, USA. May 18–21, 2018. J Urol 2018;199(4 Suppl):e707. doi: 10.1016/j.juro.2018.02.1680.
  3. Sergeeva N.S., Gitis V.G., Yurkov E.F. et al. A method for predicting the stage and aggressiveness of prostate cancer before surgery on laboratory and clinical parameters. Patent for invention. RU 2614501 C1. IPC G01N 33/48 of 03/28/2017. (In Russ.).
  4. Skachkova T.E., Sergeeva N.S., Alekseev B.Ya., Kaprin A.D. Calculator for calculating multiparameter indicators for pre-operative staging of prostate cancer. The certificate on the computer program. № 2017616515 dated 06.06.2017. (In Russ.).
  5. TNM. Classification of malignant tumors. Ed.: L.Kh. Sobin, M.K. Gospodarovich, K. Wittekind. Moscow: Logosphera, 2011. 304 p. (In Russ.).

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