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The results of treatment of urogenital system rhabdomyosarcoma in children. 15-years of experience
- Authors: Kazanstev A.P.1, Jumaniyozov K.I.2, Kerimov P.A.1, Rubanskaya M.V.1, Rubanskiy M.A.1, Kapkova O.A.1, Temnyi A.S.1, Abbasov K.A.1, Khakimov G.A.3
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Affiliations:
- N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
- Tashkent Medical Pediatric University
- Tashkent City Department, Republican Special Scientifically Practical Center of Oncology and Radiology
- Issue: Vol 15, No 2 (2019)
- Pages: 107-117
- Section: PEDIATRIC URINARY SYSTEM TUMORS
- Published: 30.06.2019
- URL: https://oncourology.abvpress.ru/oncur/article/view/939
- DOI: https://doi.org/10.17650/1726-9776-2019-15-2-107-117
- ID: 939
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Abstract
Background. Despite significount successes in treatment of rhabdomyosarcoma of urogenital system in children there are unresolved questions of choise of optimal chemotherapys combinations, intensity of chemotherapy, volumes and terms of radiotherapy, tactics of treatment residual tumors in last 3 decades.
The objective: show 15 years experience of treatment local and locally prevalent rhabdomyosarcoma urogenital system in children. The prognosis for children and adolescents with rhabdomyosarcoma has improved with refinements in multi-modal therapy.
Materials and methods. In reseach are included 86 patients with a median age of 8.4 (0.7–17) with a local genitourinary rhabdomyosarcoma, treated in N.N. Blokhin National Medical Research Centre of Oncology from 2000 to 2016. All patients were treated in different riskadopted clinical protocol included chemotherapy and radiotherapy (IRS, SIOP, CWS and local protocol DORMS-6).
Results. A 10-year overall survival and disease-free survival rates were 76 and 72 % in the entire group rhabdomyosarcoma patients, respectively.
Conclusion. The effectiveness of the risk-adopted strategy in the genitourinary rhabdomyosarcoma treatment as well as the need of new approaches and in the cases of residual viable tumor after induction chemotherapy was demonstrated.
About the authors
A. P. Kazanstev
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Email: oncoanat@mail.ru
ORCID iD: 0000-0001-7309-1650
24 Kashirskoe Shosse, Moscow 115478
Russian FederationKh. I. Jumaniyozov
Tashkent Medical Pediatric University
Email: dr.oncohikmat@inbox.ru
Department of Hospital Pediatric Surgery and Oncology
223 Bogishamol St., Tashkent 100140
UzbekistanP. A. Kerimov
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Email: polad73@mail.ru
ORCID iD: 0000-0002-3225-1109
24 Kashirskoe Shosse, Moscow 115478
Russian FederationM. V. Rubanskaya
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0002-1016-539X
24 Kashirskoe Shosse, Moscow 115478
M. A. Rubanskiy
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0001-8278-0693
24 Kashirskoe Shosse, Moscow 115478
O. A. Kapkova
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0001-5256-2193
24 Kashirskoe Shosse, Moscow 115478
A. S. Temnyi
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
Author for correspondence.
Email: krooyk93@gmail.com
ORCID iD: 0000-0001-9774-8039
24 Kashirskoe Shosse, Moscow 115478
Russian FederationKh. A. Abbasov
N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
ORCID iD: 0000-0002-0671-2995
24 Kashirskoe Shosse, Moscow 115478
G. A. Khakimov
Tashkent City Department, Republican Special Scientifically Practical Center of Oncology and Radiology
383 Farobi St., Tashkent 100179
UzbekistanReferences
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