Adjuvant chemotherapy after radical prostatectomy in patients with stage III–IV prostate cancer without distant metastases

Objective is study on the clinical efficacy of the treatment method using polychemotherapy in the docetaxel + vinorelbine regimen in patients with prostate cancer of stage III–IV without distant metastases.

Materials and methods. The study included 112 patients, who underwent radical prostatectomy on prostatic adenocarcinoma in the period 2006–2010 at N.N. Alexandrov National Cancer Center of Belarus.

Results. The developed scheme of chemotherapy after radical prostatectomy showed its effectiveness in patients with the spread of a tumor characterized by the criterion pT3b–4pN0  or pT3apN0 with Gleason sum ≤7 and prostatic specific antigen level before operation >20 ng/ml. In patients with pT3aN0 tumor with a Gleason sum ≤7 and prostatic specific antigen level before surgery <20 ng/ml, adjuvant chemotherapy is not justified.

prostate cancer, polychemotherapy, radical prostatectomy