Focal therapy of prostate cancer: patient selection, current limitations, and perspective of introduction into clinical practice

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Abstract

Focal therapy is a promising option for localized prostate cancer treatment in low and intermediate risk patients. The combination of minimal invasiveness, disease control and the possibility of re-treatment in case of recurrence have significantly increased interest in focal therapy. However, before the final introduction of focal therapy into clinical practice, a number of significant limitations have yet to be overcome, such as patient selection, visualization of target, the choice of the treatment modality and the surgery planning, as well as the development  of a follow-up protocol. Studies have shown that focal therapy has minimal impact on the quality of life, but its oncological effectiveness has yet to be evaluated in comparison with radical methods of treatment.

About the authors

A. V. Vasilyev

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Author for correspondence.
Email: alexvasilyev@me.com

Urology Department.

Build. 1, 20 Delegatskaya St., Moscow 127473

Russian Federation

A. V. Govorov

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Urology Department.

Build. 1, 20 Delegatskaya St., Moscow 127473

Russian Federation

A. A. Shiryaev

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Urology Department.

Build. 1, 20 Delegatskaya St., Moscow 127473 Russian Federation

S. O. Sukhikh

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Urology Department.

Build. 1, 20 Delegatskaya St., Moscow 127473 Russian Federation

A. A. Zherdev

Power Engineering Research Institute, Bauman Moscow State Technical University

1 Lefortovskaya Naberezhnaya

Russian Federation

A. V. Shakurov

Power Engineering Research Institute, Bauman Moscow State Technical University

1 Lefortovskaya Naberezhnaya

Russian Federation

А. V. Pushkarev

Power Engineering Research Institute, Bauman Moscow State Technical University; Department of Medical Equipment, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Department of Medical Equipment RMACPE.

1 Lefortovskaya Naberezhnaya; Build. 1, 20 Delegatskaya St., Moscow 127473 Russian Federation

D. I. Tsiganov

Power Engineering Research Institute, Bauman Moscow State Technical University; Department of Medical Equipment, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Department of Medical Equipment RMACPE.

1 Lefortovskaya Naberezhnaya; Build. 1, 20 Delegatskaya St., Moscow 127473 Russian Federation

D. Yu. Pushkar

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Urology Department.

Build. 1, 20 Delegatskaya St., Moscow 127473

Russian Federation

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