Neoadjuvant chemohormonal therapy and radical prostatectomy in a patient with lymphogenic metastatic prostate cancer

K. M. Nyushko; Нюшко К. М.; T. V. Ustinova; Устинова Т. В.; A. A. Paychadze; Пайчадзе А. А.; B. Ya. Alekseev; Алексеев Б. Я.; A. A. Krasheninnikov; Крашенинников А. А.; G. S. Gevorgyan; Геворгян Г. С.; L. V. Bolotina; Болотина Л. В.; A. S. Kalpinskiy; Калпинский А. С.; N. V. Vorob’ev; Воробьев Н. В.; A. D. Kaprin; Каприн А. Д.

doi:10.17650/1726-9776-2017-13-3-148-154

Neoadjuvant chemohormonal therapy and radical prostatectomy in a patient with lymphogenic metastatic prostate cancer

Authors: Nyushko K.M.¹, Ustinova T.V.², Paychadze A.A.¹, Alekseev B.Y.³, Krasheninnikov A.A.¹, Gevorgyan G.S.¹, Bolotina L.V.¹, Kalpinskiy A.S.¹, Vorob’ev N.V.¹, Kaprin A.D.³
Affiliations:
1. P. A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia
2. Peoples’ Friendship University of Russia
3. National Medical Research Radiological Center, Ministry of Health of Russia
Issue: Vol 13, No 3 (2017)
Pages: 148-154
Section: CLINICAL CASE
Published: 30.09.2017
URL: https://oncourology.abvpress.ru/oncur/article/view/677
DOI: https://doi.org/10.17650/1726-9776-2017-13-3-148-154
ID: 677

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Abstract

Prostate cancer (PC) is now one of the most common malignancies among men. Radical prostatectomy is the most commonly used therapy option for patients with localized PC. The appropriateness of surgical treatment for locally advanced and lymphogenic metastatic PC remains controversial, as the probability of non-radical intervention increases significantly and the risk for disease progression becomes higher. At the same time, interest in surgical treatment in patients with PC at high risk of progression, including those with lymphogenic metastases has recently increased greatly. There are more and more studies demonstrating improved survival rates in patients with high-risk PC, including those with distant metastases, who have undergone radical prostatectomy and lymphadenectomy compared with a cohort of patients who have received only drug therapy In addition to the studies evaluating the efficiency of neoadjuvant therapy before surgery in patients with localized or locally advanced high-risk PC, there are also investigations considering this option in PC patients with lymphogenic metastases. The paper gives the results of a clinical observation that shows the high efficiency of a multimodal approach with neoadjuvant chemohormonal therapy, followed by surgical treatment in a patient with lymphogenic metastatic PC.

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neoadjuvant chemohormonal therapy, surgical treatment for metastatic prostate cancer, combined chemohormonal therapy, docetaxel, novotax

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Neoadjuvant chemohormonal therapy and radical prostatectomy in a patient with lymphogenic metastatic prostate cancer

Full Text

Abstract

Keywords

About the authors

References

Supplementary files