Long-term disease control in advanced renal cell cancer with brain metastases with pazopanib (case report and literature review)

V. V. Chernova; Чернова В. В.; L. N. Volodina; Володина Л. Н.; A. V. Grigoriev; Григорьев А. В.; A. I. Smirnov; Смирнов А. И.; E. V. Shustova; Шустова Е. В.; O. P. Zhuravlеva; Журавлева О. П.; M. P. Bublikova; Бубликова М. П.; V. V. Vizhgorodskaya; Вижгородская В. В.; M. V. Shomovа; Шомова М. В.; M. G. Matyash; Матяш М. Г.

doi:10.17650/1726-9776-2015-11-3-96-100

Long-term disease control in advanced renal cell cancer with brain metastases with pazopanib (case report and literature review)

Authors: Chernova V.V.¹^,2, Volodina L.N.¹^,2, Grigoriev A.V.¹^,2, Smirnov A.I.¹^,2, Shustova E.V.¹^,2, Zhuravlеva O.P.¹^,2, Bublikova M.P.¹^,2, Vizhgorodskaya V.V.¹^,2, Shomovа M.V.¹^,2, Matyash M.G.³^,4^,5
Affiliations:
1. Ryazan Regional Clinical Oncological Dispensary
2. Russia, 390047, Ryazan, Sportivnaya St., 13
3. Novartis
4. Novartis Pharma LLC
5. 3 bldg., 72 Leningradskiy prospect, Moscow, 125315
Issue: Vol 11, No 3 (2015)
Pages: 96-100
Section: CLINICAL CASE
Published: 30.09.2015
URL: https://oncourology.abvpress.ru/oncur/article/view/495
DOI: https://doi.org/10.17650/1726-9776-2015-11-3-96-100
ID: 495

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Abstract

We report the case of advanced clear cell renal cell carcinoma with brain, pulmonary, hepatic and bone metastases treated with pazopanib.
We observed the complete response in brain metastases and stable extracranial disease after 4 years of the treatment. According to the literature review this is the first reported case of complete response to pazopanib in brain metastases in renal cell carcinoma.