Генетические маркеры предрасположенности к возникновению рака предстательной железы
https://doi.org/10.17650/1726-9776-2015-11-3-16-23
Аннотация
Рак предстательной железы (РПЖ), как и большинство онкологических патологий, относится к мультифакториальным заболеваниям, возникающим в результате взаимодействия средовых факторов и индивидуальных особенностей генотипа. Статья посвящена обзору литературы по наследственной предрасположенности к РПЖ, обусловленной как редко встречающимися мутациями генов с высокой пенетрантностью, так и наследуемыми полиморфными вариантами генов с низкой пенетрантностью. Рассмотрены клинические аспекты наличия наследственной предрасположенности к РПЖ, в частности необходимость скрининга мужчин на предмет наличия у них обоих типов наследственных нарушений для оценки риска развития данной онкопатологии.
Об авторах
М. Д. КанаеваРоссия
И. Е. Воробцова
Россия
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Рецензия
Для цитирования:
Канаева М.Д., Воробцова И.Е. Генетические маркеры предрасположенности к возникновению рака предстательной железы. Онкоурология. 2015;11(3):16-23. https://doi.org/10.17650/1726-9776-2015-11-3-16-23
For citation:
Kanaeva M.D., Orobtsova I.E. Genetic predisposition markers for prostate cancer. Cancer Urology. 2015;11(3):16-23. (In Russ.) https://doi.org/10.17650/1726-9776-2015-11-3-16-23