Genetic predisposition markers for prostate cancer

Prostate cancer (PC), like most cancers, belongs to multifactorial diseases arising from an interaction between environmental factors and
an individual’s genotype. The paper reviews the literature on the genetic predisposition to PC, which is determined by both rare gene mutations with high penetrance and inherited polymorphic genetic variants with low penetrance. The paper considers the clinical aspects of genetic predisposition to PC, among other factors, the need for male screening for both types of genetic abnormalities to assess the risk of this cancer.