Email this article MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
- Authors: Kunin I.S.1, Boboev M.M.2, Kutsenko O.S.3, Mostovich L.A.3, Aidagulova S.V.1, Grigorieva E.V.3
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Affiliations:
- Novosibirsk state medical university
- Novosibirsk regional clinics
- Institute of molecular biology and biophysics, Siberian Division of RAMS, Novosibirsk
- Issue: Vol 8, No 4 (2012)
- Pages: 48-52
- Section: PROSTATE CANCER
- Published: 30.12.2012
- URL: https://oncourology.abvpress.ru/oncur/article/view/360
- DOI: https://doi.org/10.17650/1726-9776-2012-8-4-48-52
- ID: 360
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Abstract
The search of molecular markers of metastasing and prognosis in prostate cancer remains an urgent task. In this study, we investigated the relationship of gene expression heparanase-1 (HPSE1) and D-glucuronil C5-epimerase (GLCE) with early disease relapse and metastasis of a 2,5−3 years after diagnosis. It was shown that the ratio of the expression levels of genes HPSE1/GLCE > 1 may serve as a prognostic relapse marker and trends of the tumour to metastasis. The data obtained suggest to use this option as a molecular marker for the diagnostics of metastatic process and the disease prognosis.
About the authors
I. S. Kunin
Novosibirsk state medical university
Author for correspondence.
Email: I.S.Kunin@ngs.ru
Russian Federation
M. M. Boboev
Novosibirsk regional clinics
Email: I.S.Kunin@ngs.ru
Russian Federation
O. S. Kutsenko
Institute of molecular biology and biophysics, Siberian Division of RAMS, Novosibirsk
Email: I.S.Kunin@ngs.ru
Russian Federation
L. A. Mostovich
Institute of molecular biology and biophysics, Siberian Division of RAMS, Novosibirsk
Email: I.S.Kunin@ngs.ru
Russian Federation
S. V. Aidagulova
Novosibirsk state medical university
Email: I.S.Kunin@ngs.ru
Russian Federation
E. V. Grigorieva
Institute of molecular biology and biophysics, Siberian Division of RAMS, Novosibirsk
Email: I.S.Kunin@ngs.ru
Russian Federation
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