Clinical case of locally advanced renal cell carcinoma with an inferior vena cava tumor thrombus treated with VEGFR-TKI/IO combination pembrolizumab + lenvatinib

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Abstract

The article presents a clinical case of treatment of a young man with locally advanced renal cell carcinoma with an inferior vena cava tumor thrombus above the diaphragm. Due to non-standard neoadjuvant approach of using modern tyrosine kinase inhibitors of VEGFR and immunotherapy (VEGFR-TKI/IO) combination pembrolizumab + lenvatinib, thoracotomy was avoided and complete pathological regression of the tumor was achieved. Various studies on neoadjuvant therapy of kidney cancer including in patients with tumor thrombus are discussed, and the prospects for introducing this approach into clinical practice are described.

About the authors

R. V. Orlova

City Clinical Oncological Dispensary; Saint Petersburg State University

ORCID iD: 0000-0003-4447-9458

56 Veteranov Prospekt, Saint Petersburg 198255; 7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034

Russian Federation

M. I. Shkolnik

A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Health of Russia

ORCID iD: 0000-0003-0589-7999

70 Leningradskaya St., Pesochnyy, Saint Petersburg 197758

Russian Federation

M. I. Gluzman

City Clinical Oncological Dispensary; Saint Petersburg State University

Author for correspondence.
Email: lok2008@list.ru
ORCID iD: 0000-0002-8965-8364

Mark Igorevich Gluzman

56 Veteranov Prospekt, Saint Petersburg 198255; 7–9 Universitetskaya Naberezhnaya, Saint Petersburg 199034

Russian Federation

O. A. Bogomolov

A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Health of Russia

ORCID iD: 0000-0002-5860-9076

70 Leningradskaya St., Pesochnyy, Saint Petersburg 197758

Russian Federation

A. V. Kozlov

A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Health of Russia

ORCID iD: 0000-0002-6878-6762

70 Leningradskaya St., Pesochnyy, Saint Petersburg 197758

Russian Federation

S. A. Sidorova

A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Health of Russia

ORCID iD: 0000-0002-6298-9809

70 Leningradskaya St., Pesochnyy, Saint Petersburg 197758

Russian Federation

I. O. Rutkin

A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Health of Russia

ORCID iD: 0000-0002-9018-0433

70 Leningradskaya St., Pesochnyy, Saint Petersburg 197758

Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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