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THE ACTIVITY OF PROTEASOMES AND THEIR SUBUNIT COMPOSITION IN CANCER OF THE KIDNEY AND URINARY BLADDER
- Authors: Spirina L.V.1, Kondakova I.V.1, Usynin E.A.1, Sharova N.P.2
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Affiliations:
- Cancer Research Institute, Siberian Branch, Russian Academy of Medical Sciences, Tomsk
- N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
- Issue: Vol 6, No 3 (2010)
- Pages: 12-15
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER
- Published: 30.09.2010
- URL: https://oncourology.abvpress.ru/oncur/article/view/189
- DOI: https://doi.org/10.17650/1726-9776-2010-6-3-12-15
- ID: 189
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Abstract
The study revealed a reduction in the chemotrypsin-like activity of the total pool of proteasomes and their 26S and 20S pools in the tissue of clear-cell carcinoma of the kidney versus intact tissue. Renal cancer tissue was found to contain the higher levels of the proteasome subunits α1α2α3α5α6α7 than did intact tissues, which was accompanied by the lower content of the subunits LMP2 and PA28β. A urinary bladder tumor showed the enhanced activity of the 26S proteasomes and the lower expression of α1α2α3α5α6α7 and the elevated level of the LMP2 subunit as part of proteasomes. Intact renal tissue 26S proteasome activity was found to be related to late tumor spread. Urinary bladder cancer tissue showed a correlation between the expression of the proteasome subunits α1α2α3α5α6α7 and the size of a tumor and that between 26 proteasome activity and the degree of histological tumor differentiation.
About the authors
L. V. Spirina
Cancer Research Institute, Siberian Branch, Russian Academy of Medical Sciences, Tomsk
Author for correspondence.
Email: gusi70@list.ru
Russian Federation
I. V. Kondakova
Cancer Research Institute, Siberian Branch, Russian Academy of Medical Sciences, Tomsk
Email: gusi70@list.ru
Russian Federation
E. A. Usynin
Cancer Research Institute, Siberian Branch, Russian Academy of Medical Sciences, Tomsk
Email: gusi70@list.ru
Russian Federation
N. P. Sharova
N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
Email: gusi70@list.ru
Russian Federation
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