Brachytherapy for organ-preserving treatment of bladder cancer

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Abstract

Bladder cancer is the 9th most common malignant tumor worldwide. Muscle-invasive bladder cancer is an aggressive malignant neoplasm with a tendency for early metastases. The main approach for muscle-invasive bladder cancer treatment is radical cystectomy with lymph node dissection and polychemotherapy. In recent decades, organ-preserving conservative therapy has been actively investigated. Currently, the most studied approach to organ-preserving treatment of muscle-invasive bladder cancer is the trimodality therapy which includes transurethral resection of the bladder wall with the tumor, chemotherapy, and external beam radiotherapy. The article presents an approach which additionally includes intratumoral radiation therapy. In our study, we have investigated the current state of brachytherapy in bladder cancer treatment and its development.

About the authors

I. N. Zaborskiy

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Author for correspondence.
Email: i.zaborskii@mail.ru
ORCID iD: 0000-0001-5988-8268

Ivan Nikolaevich Zaborskiy

10 Marshala Zhukova St., Obninsk 249031

Russian Federation

K. N. Safiullin

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0002-3029-9213

10 Marshala Zhukova St., Obninsk 249031

E. I. Smolenov

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0003-3782-7338

10 Marshala Zhukova St., Obninsk 249031

E. O. Shchukina

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0001-5431-8696

10 Marshala Zhukova St., Obninsk 249031

V. S. Chaykov

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0002-8711-4937

10 Marshala Zhukova St., Obninsk 249031

A. V. Troyanov

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0001-7025-5365

10 Marshala Zhukova St., Obninsk 249031

I. O. Dementiev

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0003-2780-9822

10 Marshala Zhukova St., Obninsk 249031

O. B. Karyakin

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0002-6112-2840

10 Marshala Zhukova St., Obninsk 249031

S. A. Ivanov

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia;
Peoples’ Friendship University of Russia named after Patrice Lumumba

ORCID iD: 0000-0001-7689-6032

10 Marshala Zhukova St., Obninsk 249031;
6 Miklukho-Maklaya St., Moscow 117198

;

A. D. Kaprin

Peoples’ Friendship University of Russia named after Patrice Lumumba;
National Medical Research Radiological Center, Ministry of Health of Russia;
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0001-8784-8415

6 Miklukho-Maklaya St., Moscow 117198;
4 Koroleva St., Obninsk 249036;
3 2nd Botkinskiy Proezd, Moscow 125284

 

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