Correlation between 3D morphometric characteristics of kidney tumors and their histological structure

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Abstract

Aim. To assess the correlation between clinical characteristics (sex, age, and maximum tumor size), 3D morphometric characteristics of renal lesions obtained through processing of multispiral computed tomography data, and renal tumor histology.

Materials and methods. Evaluation of kidney tumor malignancy on the basis of comparative analysis of primarily morphometric characteristics of the lesion obtained through processing of multispiral computed tomography data and histological tumor structure is presented. Data of 308 patients (175 (56.8 %) males and 133 (43.2 %) females) with unilateral renal tumors were analyzed.

Results. Multivariable analysis showed that malignancy of kidney tumor is associated with sex (male), location in the middle segment, tumor size, tumor shape (spherical with conical base) (24.8 %), while mushroom-like lesion shape was more common in benign tumors (35.2 %). In univariate models, only two variables were statistically significant predictors: patient sex and tumor shape.

Conclusion. The developed logistic model based on analysis of such predictors as sex and kidney tumor shape has a high percentage (87.6 %) of correct predictions of tumor histological structure.

About the authors

D. N. Fiev

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Author for correspondence.
Email: fiev@mail.ru
ORCID iD: 0000-0002-0401-8780

Dmitriy Nikolaevich Fiev

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

E. S. Sirota

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: essirota@mail.ru
ORCID iD: 0000-0001-6419-0155

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia

Russian Federation

V. V. Kozlov

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: kvv.doc@gmail.com
ORCID iD: 0000-0002-2389-3820

N.A. Semashko Department of Public Health and Healthcare

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia

Russian Federation

A. V. Proskura

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: proskura777@yandex.ru
ORCID iD: 0000-0003-0441-4799

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

E. V. Shpot

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: shpot_e_v@staff.sechenov.ru
ORCID iD: 0000-0003-1121-9430

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

M. M. Chernenkiy

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: chernenkiy_m_m@staff.sechenov.ru
ORCID iD: 0000-0002-4001-5317

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

I. M. Chernenkiy

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: chernenkiy_i_m@staff.sechenov.ru
ORCID iD: 0000-0001-5968-9883

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

K. B. Puzakov

Scientific and Practical Clinical Center for Diagnostics and Telemedicine Technologies, Moscow Healthcare Department

Email: mrictdoc@mail.ru
ORCID iD: 0000-0001-9017-8205

Build. 1, 24 Petrovka St., Moscow 127051, Russia

Russian Federation

K. R. Azil’gareeva

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: camilla.azilgareeva@yandex.ru
ORCID iD: 0000-0002-7096-7423

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

Kh. M. Ismailov

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: halilismailov2013@mail.ru
ORCID iD: 0000-0003-0548-190X

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

D. V. Butnaru

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: butnaru_d_v@staff.sechenov.ru
ORCID iD: 0000-0003-2173-0566

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

A. Kutikov

Fox Chase Cancer Center

Email: alexander.kutikov@fccc.edu
ORCID iD: 0000-0003-1525-6247

333 Cottman Avenue, Philadelphia, PA 19111 USA 

United States

A. Z. Vinarov

Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: avinarov@mail.ru
ORCID iD: 0000-0001-9510-9487

Build. 1, 2 Bol’shaya Pirogovskaya St., Moscow 119435, Russia 

Russian Federation

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