BRAIN METASTASES OF GERM CELL TUMORS. THE RUSSIAN CANCER RESEARCH CENTER'S EXPERIENCE

A. A. Tryakin; Трякин А. А.; M. Yu. Fedyanin; Федянин М. Ю.; A. A. Bulanov; Буланов А. А.; A. Kh. Bekyashev; Бекяшев А. Х.; V. A. Aleshin; Алешин В. А.; Z. P. Mikhina; Михина З. П.; V. B. Matveev; Матвеев В. Б.; T. I. Zakharova; Захарова Т. И.; A. M. Garin; Гарин А. М.; S. A. Tyulyandin; Тюляндин С. А.

doi:10.17650/1726-9776-2013-9-4-59-65

BRAIN METASTASES OF GERM CELL TUMORS. THE RUSSIAN CANCER RESEARCH CENTER'S EXPERIENCE

Authors: Tryakin A.A.¹, Fedyanin M.Y.¹, Bulanov A.A.¹, Bekyashev A.K.¹, Aleshin V.A.¹, Mikhina Z.P.¹, Matveev V.B.¹, Zakharova T.I.¹, Garin A.M.¹, Tyulyandin S.A.¹
Affiliations:
1. N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Issue: Vol 9, No 4 (2013)
Pages: 59-65
Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. TESTICULAR CANCER
Published: 30.12.2013
URL: https://oncourology.abvpress.ru/oncur/article/view/150
DOI: https://doi.org/10.17650/1726-9776-2013-9-4-59-65
ID: 150

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Abstract

This paper analyzes the experience in treating 20 patients with nonseminomatous germ cell tumors metastasizing to the brain. It presents brain metastasis-associated factors: multiple lung metastases; IGCCCG poor prognosis; and a baseline human chorionic gonadotropin level of > 50000 mIU/ml. The authors have identified a group to be screened for brain metastasis, which includes patients with intermediate/poor prognosis and multiple lung metastases. Long-term survival was achieved in 45 % of patients with baseline brain damage and in 22 % of those with metastases revealed after first-line chemotherapy. The positive prognostic factors associated with long-term survival were a single brain lesion, no neurological symptoms, and achievement of clinical complete personse in the brain.