Диферелин® как эффективный препарат кастрационной терапии у больных раком предстательной железы
https://doi.org/10.17650/1726-9776-2020-16-4-191-196
Аннотация
Андроген-депривационная терапия является одним из основных методов лечения больных местно-распространенным и метастатическим раком предстательной железы. Она направлена на снижение уровня тестостерона. Несмотря на появление в последние годы новых эффективных препаратов, в качестве андроген-депривационной терапии чаще применяют агонисты лютеинизирующего гонадотропин-рилизинг-гормона. Одним из наиболее часто используемых препаратов 1-й линии является трипторелин (диферелин®). В России трипторелин применяется в лекарственных формах с замедленным высвобождением с частотой введения 1 раз в 1, 3 мес при внутримышечных инъекциях, а также при подкожных инъекциях с частотой введения 1 раз в 3 мес, при этом результат применения разных лекарственных форм сопоставим между собой. Трипторелин эффективно обеспечивает и поддерживает уровень тестостерона в сыворотке крови ниже 20 нг/дл, что увеличивает время до развития кастрационно-резистентного рака предстательной железы, увеличивает общую выживаемость больных при комбинированной терапии с применением лучевого лечения, а также снижает степень тяжести симптомов со стороны нижних мочевыводящих путей. Трипторелин имеет известный профиль безопасности и в целом хорошо переносится пациентами.
Об авторах
К. М. Нюшко
ФГБУ Национальный медицинский исследовательский центр радиологии» Минздрава России;
Россия
125284 Москва, 2-й Боткинский проезд, 3
Конфликт интересов: нет
Россия
125284 Москва, 2-й Боткинский проезд, 3
Конфликт интересов: нет
В. М. Перепухов
ФГБУ Национальный медицинский исследовательский центр радиологии» Минздрава России
Россия
125284 Москва, 2-й Боткинский проезд, 3
Конфликт интересов: нет
Россия
125284 Москва, 2-й Боткинский проезд, 3
Конфликт интересов: нет
Б. Я. Алексеев
ФГБУ Национальный медицинский исследовательский центр радиологии» Минздрава России; Медицинский институт непрерывного образования, ФГБОУ ВО Московский государственный университет пищевых производств
Россия
Конфликт интересов: нет
Россия
125284 Москва, 2-й Боткинский проезд, 3; 125080 Москва, Волоколамское шоссе, 11
Конфликт интересов: нет
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Рецензия
Для цитирования:
Нюшко К.М., Перепухов В.М., Алексеев Б.Я. Диферелин® как эффективный препарат кастрационной терапии у больных раком предстательной железы. Онкоурология. 2020;16(4):191-196. https://doi.org/10.17650/1726-9776-2020-16-4-191-196
For citation:
Nyushko K.M., Perepukhov V.M., Alekseev B.Y. Diferelin® as an effective chemical castration agent for patients with prostate cancer. Cancer Urology. 2020;16(4):191-196. (In Russ.) https://doi.org/10.17650/1726-9776-2020-16-4-191-196
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