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ROLE OF MULTIPARAMETRIC MRI IN THE DETECTION AND LOCALIZATION OF EARLY-STAGE PROSTATE CANCER
- Authors: Akhverdieva G.I.1,2, Sanai E.B.1, Panov V.O.1,2,3, Tyurin I.E.1,2, Gubsky I.L.2, Kamolov B.S.1, Khachaturyan A.V.1
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Affiliations:
- Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
- Russian Medical Academy of Postgraduate Education, Moscow
- N.I. Pirogov Russian National Research Medical University, Moscow
- Issue: Vol 9, No 4 (2013)
- Pages: 25-36
- Section: PROSTATE CANCER
- Published: 30.12.2013
- URL: https://oncourology.abvpress.ru/oncur/article/view/140
- DOI: https://doi.org/10.17650/1726-9776-2013-9-4-25-36
- ID: 140
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Abstract
The efficiency of prostate cancer (PC) diagnosis using multipatametric magnetic resonance imaging (MRI) was evaluated. Unlike most of investigations of the similar problem, this trial provides an objective assessment applying the method of statistical analysis - binary logistic regression. It used data on 166 patients, including primary patients (with suspected PC), as well as patients with the established diagnosis of PC, those with a history of negative biopsy, and those with suspected recurrent PC. Some patients underwent target biopsy, the results of which were then employed for statistical processing. The data of the analysis showed that the sensitivity, specificity, and total accuracy of the method using the created model of binary logistic regression at the separation value of 0.625 were 75.0, 85.2, and 79.7%, respectively. The efficiency of diffusion-weighted images (DWI) with varying weighing degree by water molecule diffusion (b factor) on MRI systems with different magnetic field strength (1.5 and 3 Tesla) was also evaluated. There were no statistically significant differences in normalized absolute signal intensity as to the contralateral gland portion) in DWI with b factors of 1000 and 2000 between the MRI systems with a magnetic field strength of 1.5 and 3.0 Tesla.
About the authors
G. I. Akhverdieva
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow;Russian Medical Academy of Postgraduate Education, Moscow
Author for correspondence.
Email: doctor_gulya@mail.ru
Department of Radiodiagnosis, Radiotherapy, and Medical Physics
Russian FederationE. B. Sanai
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: doctor_gulya@mail.ru
Russian Federation
V. O. Panov
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow;Russian Medical Academy of Postgraduate Education, Moscow;
N.I. Pirogov Russian National Research Medical University, Moscow
Email: doctor_gulya@mail.ru
Department of Radiodiagnosis, Radiotherapy, and Medical Physics
Russian FederationI. E. Tyurin
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow;Russian Medical Academy of Postgraduate Education, Moscow
Email: doctor_gulya@mail.ru
Department of Radiodiagnosis, Radiotherapy, and Medical Physics
Russian FederationI. L. Gubsky
Russian Medical Academy of Postgraduate Education, Moscow
Email: doctor_gulya@mail.ru
Department of Radiodiagnosis, Radiotherapy, and Medical Physics
Russian FederationB. Sh. Kamolov
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: doctor_gulya@mail.ru
Russian Federation
A. V. Khachaturyan
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: doctor_gulya@mail.ru
Russian Federation
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