Nosocomial infectious complications in patients with urological malignancies

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Abstract

The objective of the study was to analyze the taxonomic structure of urinary infection pathogens and determine the susceptibility of ESKAPE group microorganisms (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus spp.) isolated from cancer patients with nosocomial infections in 2018—2020 to antimicrobials.

Materials and methods. 413 (71.9 %) strains of ESKAPE group bacteria from 228 patients were studied. Microorganisms were identified and antibiotic resistance was determined using Vitek-2 System (France) and MicroScan WalkAway (Germany / USA) analyzers.

Results and conclusion. All gram-positive microorganisms were highly sensitive to vancomycin and teicoplanin, linezolid, tigecycline, and daptomycin, which can be used in the treatment if clinical indications are seen. Among gram-negative bacteria, the percentage of ESBL producers was 60—70 %, the percentage of carbapenem-resistant bacteria was minimalfor E. coli, rnmpared to the rest - 40—50 %, demonstrating the need to limit the use of carbapenems in the clinic.

About the authors

N. V. Dmitrieva

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: prof.ndmitrieva@mail.ru

24 Kashirskoe Shosse, Moscow 115478.

Russian Federation

V. V. Aginova

Medical College No. 1

Author for correspondence.
Email: avkn@mail.ru
ORCID iD: 0000-0003-1787-2676

35A Leninskiy Prospekt, Moscow 119071.

Russian Federation

I. N. Petukhova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: irinapet@list.ru
ORCID iD: 0000-0003-3077-0447

24 Kashirskoe Shosse, Moscow 115478.

Russian Federation

E. N. Sokolova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: sokolen@mail.ru

24 Kashirskoe Shosse, Moscow 115478.

Russian Federation

S. A. Dyakova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: dyakova_bact@mail.ru

24 Kashirskoe Shosse, Moscow 115478.

Russian Federation

Z. V. Grigoryevskaya

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: zlatadoc@list.ru
ORCID iD: 0000-0003-4294-1995

24 Kashirskoe Shosse, Moscow 115478.

Russian Federation

E. N. Kulaga

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: kulagaev@list.ru

24 Kashirskoe Shosse, Moscow 115478.

Russian Federation

References

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  11. Naber K.G., Schito G., Botto H. et al. Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy. Eur Urol 2008;54(5):1164-75. doi: 10.1016/j.eururo.2008.05.010.
  12. Bonkat G. (Chair), Bartoletti R., Bruyere F. et al. EUA Guadelines Urological Infections, 2020.

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