Metastatic testicular and epididymal lesions in a patient with advanced prostate cancer: a case report and literature review

Cover Page

Cite item

Full Text

Abstract

Prostate cancer (PCa) is a second of the most commonly diagnosed carcinoma in the male population. Usually sites of secondary lesions are lymph nodes and bones. Most cases of testicular metastases are incidentally diagnosed after orchiectomy.

We present a case of 62-year-old man with metastatic castration-resistant PCa and symptomatic testicular metastasis with contralateral epididymal metastasis. Right site radical orchiectomy and left site orchiectomy was performed. The pathology report identified PCa metastases in the right testis and in the left epididymis.

Testicular and epididymal metastases are uncommon in PCa. Therefore, a testicular physical examination is necessary for patients with PCa. Physicians have to keep in mind the possibility of testicular metastasis in cases of biochemical recurrence and progression of the disease.

About the authors

S. A. Reva

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of Russia;

ORCID iD: 0000-0001-5183-5153

6—8L’va Tolstogo St., Saint-Petersburg 197022

Russian Federation

A. A. Lyublinskaya

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of Russia;

Author for correspondence.
Email: 7505898@mail.ru
ORCID iD: 0000-0003-3592-3107

6—8L’va Tolstogo St., Saint-Petersburg 197022

Russian Federation

D. G. Prokhorov

Russian Scientific Center for Radiology and Surgical Technologies named after acad. A.M. Granova, Ministry of Health of Russia

ORCID iD: 0000-0001-5795-337X

70 Leningradskaya St., Pesochnyy, Saint-Petersburg 197758

Russian Federation

K. G. Pygamov

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of Russia;

ORCID iD: 0000-0002-1904-5108

6—8L’va Tolstogo St., Saint-Petersburg 197022

Russian Federation

A. G. Tyurin

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of Russia;

6—8L’va Tolstogo St., Saint-Petersburg 197022

Russian Federation

А. M. Sycheva

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of Russia;

6—8L’va Tolstogo St., Saint-Petersburg 197022

Russian Federation

S. B. Petrov

I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of Russia;

6—8L’va Tolstogo St., Saint-Petersburg 197022

Russian Federation

References

  1. Bubendorf L., Schopfer A., Wagner U. et al. Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients. Human Pathology 2000; 5:31 78-83. [PubMed: 10836297]
  2. Schneider A., Kollias A., Woziwodzki J., Stauch G. Hodenmetastase eines metachronen kleinzelligen neuroendokrinen Prostatakarzinoms nach Hormontherapie eines Adenokarzinoms der Prostata. Der Urologe 2006; 01:45 75-80. DOI.10.1007/s00120-005-0945-y
  3. Thon W., Mohr W., Altwien J.A. Testicular and Epididymal Metstasis of Prostate Cancer. Case Reports. American research journal of urology1985;24 (5):287-90 PMID: 4060378
  4. Semans J.H. Carcinoma of the Prostate with Metastasis in the Testis. The Journal of Urology, 1938;40(4): 524–529. doi: 10.1016/s0022-5347(17)71794-6
  5. Pienkos E.J., Jablokow K.R.. Secondary testicular tumors. Cancer1972;30: 481-5. doi: 10.1002/1097-0142(197208)30:2<481::aid-cncr2820300228>3.0.co;2-x. PMID: 5051673
  6. Bauduceau O., Vedrine L., Chargari C. et al. Metastase testiculare d’un adenocarcinoma prostatique: a propos d’un cas. Progres en Urologie 2007;17:251-252 doi: 10.1016/s1166-7087(07)92274-5
  7. Hsieh T.C., Lin C.C., Kao C.H. et al. Asymptomatic Solitary Metastasis to the Testis From Prostate Carcinoma Detected by FDG PET/CT. Clinical nuclear medicine 2016;41: 86-87. doi: 10.1097/RLU.0000000000001004
  8. Giannakopoulos X., Bai M., Grammeniatis E. et al. Bilateral Testicular Metastasis of an Adenocarcinoma of the Prostate. Annals of Urological Research 1994;28(5):274-6. PMID: 7825987
  9. Mortensen M.A., Engvad B., Greertsen L. et al. Metastasis in Testis From Prostate Cancer. Ugeskr Laeger 2014;176(13). PMID: 25349932
  10. Deb P., Chander Y., Rai R.S. Testicular metastasis from carcinoma of prostate: report of two cases. Prostate Cancer and Prostatic Diseases 2007; 10:202-204; doi: 10.1038/sj.pcan.4500942.
  11. Moskovitz B., Kerner H., Levin D.R. Testicular Metastasis from Carcinoma of the Prostate. Urologia internationals 1987;42:79-80 doi: 10.1159/000281859 PMID: 3590410
  12. Sampathrajan S., Garga G., Gupta S. et al. Incidentally Detected Testicular Metastasis in a Case of Prostatic Adenocarcinoma. Journal of Clinical and Diagnostic Research. 2015;9(12) doi: 10.7860/JCDR/2015/15849.6884
  13. Kim S.O., Choi Y.D., Jung S. et al. Prostate Cancer with Solitary Metastases to the Bilateral Testis. doi: 10.3349/ymj.2011.52.2.362
  14. Gao Q., Chen J., Dai Y. Prostate cancer involving bilateral seminal vesicles along with bone and testicular metastases: a case report. Gao et al. Journal of Medical Case Reports 2018;12:72. doi: 10.1186/s13256-017-1551-5
  15. Baykal K., Yildirim S., Inal H. et al. Metastasis of Prostate Adenocarcinoma to Testis. International journal of urology 1997;4:104-105. PMID: 9179680 doi: 10.1111/j.1442-2042.1997.tb00153.x
  16. Zhang J., Dong M., Hu X. et al. Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report. DOI: 10/3892/ol.2015.3920
  17. Menon S., Gujral S., Bakshi G., Tongaonkar H.B. Bilateral testicular metastasis from prostatic adenocarcinoma mimicking an intertubular pattern of seminoma and expressing Rhamm. Journal of Cancer Research and Therapeutics 2010;6(1):97-9. doi: 10.4103/0973-1482.63560.
  18. Zrara I., Touiti D., Rimani M. et al. Testicular Metastasis of Prostatic Adenocarcinoma:Report of 2 Cases. Annals of Urological Research 2000;34(3):200-2. PMID: 10953800
  19. Baydar D.E., Kosemehmetoglu K., Akdogan B., Ozen H. Prostatic Adenosquamous Carcinoma Metastasizing to Testis. The scientific world journal 2006; 6:2491-2494. doi: 10.1100/tswurol.2006.388
  20. Talbot R.W., McCann B.G. Secondary Prostatic Tumour of the Spermatic Cord and Epididymis 5 Years After Prostatectomy and Vasectomy. British journal of urology 1979;51:48 PMID: 465962 doi: 10.1111/j.1464-410x.1979.tb04246.x
  21. Haupt B., Ro J.Y., Ayala A.G., Zhai J. Metastatic Prostatic Carcinoma to Testis: Histological Features Mimicking Lymphoma. International journal of clinical and experimental pathology 2009;2:104-107 PMID: 18830384 PMCID: PMC2491390
  22. Benchekroun A., Kasmaoui E.H., Ghadouane M. et al. Metastase testiculare d’un adenocarcinoma prostatique: a propos d’un cas. Annals d`urologie 2001; 35:234-6 PMID: 11355278 doi: 10.1016/s0003-4401(01)00010-9
  23. Su J., Aslim E.J., Aydin H. et al. A rare case of isolated castrate resistant bilateral testicular metastases in advanced prostate cancer. doi: 10.1016/.2017.03.001
  24. Lyngdorf P., Nielsen K. Prostatic Cancer with Metastasis to the Testis. Urologia internationalis 1987;42: 77-78 PMID: 3590409 doi: 10.1159/000281858
  25. Upchurch E.A., Khan F., Okeke A. Symptomatic bilateral testicular metastasis from carcinoma of the prostate. doi: 10.1136/brc-2013-009008
  26. Rahardjo H.E., Umbas R., Sutisna H. Testikular Metastases From Prostate Carcinoma. Asian journal of surgery 2010:33(3):154-6 PMID: 21163414 doi: 10.1016/S1015-9584(10)60026-7
  27. Kusaka A., Koie T., Yamamoto H. et al. Testicolar Metastasis of Prostate Cancer: A Case Report. Case reports in oncology 2014;7:643-647 doi: 10.1159/000367779
  28. Grignon D.J., Shum D.T., Hayman W.P.. Metostatic Tumours of the Testes. Case Reports. Canadian journal of surgery 1986;29(5):359-61. PMID: 3756659
  29. Inaba Y., Okamoto M., Harada M. et al. Prostatic Carcinoma With Bilaretal Testicular Metastasis: A Case Report. Hinyokika Kiyo 1994;40(3):249-52. PMID: 8178745
  30. Campara Z., Simic D., Aleksic P. et al. Metastasis of Prostate Adenocarcinoma to the Testis. Medical archives (Sarajevo, Bosnia and Herzegovina) 2016;70(4):318-320. doi: 10.5455/medarh.2016.70.318-320
  31. Heidrich А., Bollman R., Knipper A. Hodenmetastase eines Prostatakarzinoma drei Jahre nach subkapsularer Orchiektomie. Der Urologe.Ausg.A 1999;38:279-281 PMID: 10407989 doi: 10.1007/s001200050282
  32. Menchini-Fabris F., Giannarini G., Pomara G. et al. Case Report. Testicular metastasis as isolated recurrence after radical prostatectomy. A first case. International Journal of Impotence Research 2017;19,108-109 PMID: 16554855 doi: 10.1038/sj.ijir.3901460
  33. Janssen S., Bernhards J., Aristotelis G. et al. Solitary Testicular Metastasis from Prostate Cancer: A Rare Case of Isolated Recurrence after Rasical Prostatectomy. Anticancer Research 2010;30:1747-1750 PMID: 20592373
  34. Bonetta A., Generali D., Corona S.P. et al. Isolated Testicular Metastasis from Prostate Cancer. The American journal of case reports. 2017;18:887-889 doi: 10.12659/AJCR.904521
  35. Dahiru A., Raheem N., Nggada H.A. et al. Isolate Testicular Metastasis from Prostatic Adenocarcinoma. Annal of African medicine. 2019;18(3):173-175. doi: 10.4103/aam.aam_60_18: 10.4103/aam.aam_60_18
  36. Manikanda R., Nathaniel C., Reeve N., Brough R.J. Bilateral testicular metastases from prostatic carcinoma. Case Report. International Journal of Urology. 2006;13:476-477 PMID: 16734881 doi: 10.1111/j.1442-2042.2006.01329.x
  37. Rizk C.C, Scholes J., Chen S.K. et al. Epididymal metastasis from prostatic adenocarcinoma mimicking adenomatoid tumor. Urology. 1990;36:526-30 PubMed:1701066
  38. Addonizio J.C., Thelmo W. Epididymal metastasis from prostatic carcinoma. Urology. 1981;18:490-1. PubMed: 7314342
  39. Santos-Lopes S., Lobo J., Henrique R., Oliveira J. Epididymal metastasis from prostate adenocarcinoma: An unusual and challenging diagnosis suspected in gallium-68 prostate-specific membrane antigen-positron emission tomography/computed tomography and histologically confirmed. Annals of urological research2017; 9(1):89-91. doi: 10.4103/0974-7796. 198886: 10.4103/0974-7796.198886
  40. Tu S.M., Reyes A., Maa A. et al. Prostate Carcinoma with Testicular or Penile Metastases. Clinical, Pathologic, and Immunohistochemical Features. Supported in part by National Cancer Institute Core Grant CA 16672 PMID: 12173328 doi: 10.1002/cncr.10546
  41. Anila K.R., Somanathan T., Mathews A., Jayasree K. An Ususual Variant of Prostatic Adenocarcinoma With Metastasis to Testis. A case Report. Abstract. The Gulf journal of oncology 2012;(12):73-6. PMID: 22773221
  42. Weitzner S. Survival of Patients With Secondary Carcinoma of Prostate in the Testis. American cancer society journals 1973;32(2):447-449
  43. Bordes A.R., Gonzalez M.M., Algaba-Arrea H.V. Carcinoma metatstasico testicular. Monografico cancer de testiculo. Archivos espanoles de urologia. 2000;53(6):469-71 PMID: 11002514

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c)


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-36986 от  21.07.2009.