Organ-preserving surgery: current line of therapy in children with nephroblastoma (a review of the literature and the author's own clinical findings)

Abstract

Nephroblastoma (NB) is a tumor that frequently occurs in childhood. Progress in therapy of NB is associated with the development of modern radio and chemotherapy. Contemporary chemotherapy allows for an organ-preserving treatment of patients with NB. The author’s experience gained at the Research Institute of Pediatric Oncology and Hematology (RIPOH), N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences is presented. Data on 120 patients aged 6 months to 12 months, who were treated with organ-preserving operations of different types and extent, are analyzed. A clinical classification of NB in children and a working classification of bilateral NB, which has been developed at the RIPOH, are provided. The technique of different types of organ-preserving surgery in children with NB is described as well as the long-term results of treatment.