Cytogenetic studies of bilateral renal cell carcinoma

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Abstract

Aim. To study chromosomal abnormalities in bilateral renal cell carcinoma (RCC).

Materials and methods. Paraffin-embedded specimens from 8 patients with bilateral RCC were examined by comparative genomic hybridization.

Results. 1 to 6 chromosomal aberrations were found in each sample. The same chromosomal aberrations in both tumors in 7 (87.5%) cases chromosomal changes were different in one (12.5%) case.

Conclusion. Further genetic studies of bilateral RCC may give a better insight into the biology, diagnosis, and treatment of bilateral RCC.

About the authors

V. B. Matveyev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Author for correspondence.

Отделение урологии

Russian Federation

T. V. Marilov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences

Отделение урологии

Russian Federation

K. Junker

Jena University Urology Clinic

Germany

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