Prognostic value of expression of thymidine phosphorylase, Bcl-2, and Ki-67 in renal cancer T1-2N0M0

S. L. Gutorov; Гуторов С. Л.; Ye. V. Stepanova; Степанова Е. В.; Ya. V. Vishnevskaya; Вишневская Я. В.; Ye. V. Chernoglazova; Черноглазова Е. В.; I. N. Sokolova; Соколова И. Н.; V. B. Matveev; Матвеев В. Б.

doi:10.17650/1726-9776-2007-3-4-21-25

Prognostic value of expression of thymidine phosphorylase, Bcl-2, and Ki-67 in renal cancer T1-2N0M0

Authors: Gutorov S.L.¹, Stepanova Y.V.¹, Vishnevskaya Y.V.¹, Chernoglazova Y.V.¹, Sokolova I.N.¹, Matveev V.B.¹
Affiliations:
1. N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Issue: Vol 3, No 4 (2007)
Pages: 21-25
Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER
Published: 30.12.2007
URL: https://oncourology.abvpress.ru/oncur/article/view/1133
DOI: https://doi.org/10.17650/1726-9776-2007-3-4-21-25
ID: 1133

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Abstract

The incidence of the relapse following radical nephrectomy for renal cancer is as high as 20—30%. The traditional predictors (including the histological type of a tumor) are insufficient to predict the likelihood of the relapse. The authors studied the expression of a number of molecular markers including thymidine phosphorylase (TP), Bcl-2, and Ki-67 and their prognostic value in patients with renal cancer (T1—2N0M0). The risk of progression significantly increased in higher grade of the tumor and in cases of TP hyperexpression. The favorable prognostic factors may include the absence of PT expression on the tumor cells.