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Expression of human interleukin-6 and its viral homologue in prostate cancer tissue
- Authors: Veliyev Y.I.1, Rybalchenko A.V.1, Shirokov D.A.2, Tupitsyn N.N.2
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Affiliations:
- Russian Medical Academy of Postgraduate Education
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
- Issue: Vol 3, No 1 (2007)
- Pages: 65-68
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCER
- Published: 30.03.2007
- URL: https://oncourology.abvpress.ru/oncur/article/view/1090
- DOI: https://doi.org/10.17650/1726-9776-2007-3-1-65-68
- ID: 1090
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Abstract
Human interleukin-6 (IL-6) is of considerable importance in the pathogenesis of prostate cancer (PC). Prostatic cells are also known to be a reservoir for human herpesvirus 8 type (HHV-8). Due to the findings that HHV-8 had a homologue of human IL-6, viral IL-6, it seemed interesting to study the expression of these two cytokines in the tumor tissue of patients with PC. The expression of IL-6 mRNA was found in 70% of the patients. That of viral IL-6 was not detected in this disease. Nevertheless, a genetic HHV-8 material was ascertained in the tumor tissue of 2 patients with PC.
About the authors
Yе. I. Veliyev
Russian Medical Academy of Postgraduate Education
Author for correspondence.
Department of Urology and Surgical Andrology Russian Federation
A. V. Rybalchenko
Russian Medical Academy of Postgraduate EducationDepartment of Urology and Surgical Andrology Russian Federation
D. A. Shirokov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesLaboratory of Immunology of Hemopoiesis Russian Federation
N. N. Tupitsyn
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesLaboratory of Immunology of Hemopoiesis Russian Federation
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