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Diagnostic potentials of combined detection of amidolytic activity of hepsin and GSTP1 gene methylation in patients with malignant and other prostate diseases
- Authors: Vassileva Y.B.1, Lyashenko A.A.1,2, Savvateeva M.V.3, Kuznetsova Y.M.3, Severin S.Y.1,3, Severin Y.S.1,4, Fiyev D.N.1, Aljaev Y.G.1, Vinarov A.Z.1
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Affiliations:
- I.M. Sechenov Moscow Medical Academy
- Center of Medical biotechnologies
- Moscow Institute of Medical Ecology
- Research Center for Molecular Diagnostics & Therapy
- Issue: Vol 4, No 3 (2008)
- Pages: 50-53
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCER
- Published: 30.09.2008
- URL: https://oncourology.abvpress.ru/oncur/article/view/1067
- DOI: https://doi.org/10.17650/1726-9776-2008-4-3-50-53
- ID: 1067
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Abstract
We have assessed the implication of analysis of amydolitic activity of hepsin, which is a trans-membrane serine protease of II type, in the detection of prostate cancer diagnosis. According to literature review over-expression of hepsin is characteristic for prostate cancer whereas prostatic cells do not express this protease in normal states and benign tumors of prostate. Our results have demonstrated the value of screening for hepsin activity in the diagnosis of prostatic pathologies which possibly is an adequate substitution for widely used test of prostate specific antigen determination.
About the authors
Ye. B. Vassileva
I.M. Sechenov Moscow Medical Academy
Author for correspondence.
Moscow Russian Federation
A. A. Lyashenko
I.M. Sechenov Moscow Medical Academy; Center of Medical biotechnologiesMoscow Russian Federation
M. V. Savvateeva
Moscow Institute of Medical EcologyMoscow Russian Federation
Ye. M. Kuznetsova
Moscow Institute of Medical EcologyMoscow Russian Federation
S. Ye. Severin
I.M. Sechenov Moscow Medical Academy; Moscow Institute of Medical EcologyMoscow Russian Federation
Ye. S. Severin
I.M. Sechenov Moscow Medical Academy; Research Center for Molecular Diagnostics & TherapyMoscow Russian Federation
D. N. Fiyev
I.M. Sechenov Moscow Medical AcademyMoscow Russian Federation
Yu. G. Aljaev
I.M. Sechenov Moscow Medical AcademyMoscow Russian Federation
A. Z. Vinarov
I.M. Sechenov Moscow Medical AcademyMoscow Russian Federation
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