Neoadjuvant hormonal therapy with bicalutamide 150 mg before radical treatment in patients with localized and locally advanced prostate cancer

Abstract

Hormonal therapy of prostate cancer is the method of choice in patients who can not be treated radically. For patients with locally advanced renal cancer the monotherapy with bicalutamide can be used as an alternative to castration.

In our study we tried to determine the degree of decrease of prostate gland volume and level of prostate specific antigen in the serum after therapy with 150 mg of bicalutamide per day. Besides, we also attempted to clarify whether preoperative or pre-radiation hormonal therapy with bicalutamide in the dose of 150 mg per day increases the time interval to clinical progression.

After hormonal therapy we observed considerable decrease of level of prostate specific antigen in the serum. Mean volume of prostate gland also has significantly diminished in comparison to pretreatment state.

The results of our study have demonstrated that therapy with bicalutamide can be an alternative approach to maximal androgenic blockage. As well, it can be used in neoadjuvant setting as hormonal therapy before radical treatment in patients with localized and locally advanced prostate cancer.