Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press94910.17650/1726-9776-2019-15-3-132-142REVIEWОБЗОРKIM-1 as a potential serological/urinological tumor-associated marker of renal cell carcinoma and chemotherapy nephrotoxicityKIM-1 (kidney injury molecule-1) как потенциальный серологический/урологический опухолеассоциированный маркер почечно-клеточного рака и нефротоксичности химиопрепаратовhttps://orcid.org/0000-0003-0676-600XSolokhinaM. P.СолохинаМ. П.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

Мариям Павловна Салохина, отделение Прогноза, научный сотрудник

125284 Москва, 2-й Боткинский проезд, 3

SPIN: 5341-9803

solomar59@mail.ruhttps://orcid.org/0000-0001-7406-9973SergeevaN. S.СергееваН. С.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284, 

1 Ostrovityanova St., Moscow 117997

Наталья Сергеевна Сергеева

117997 Москва, ул. Островитянова, 1, 

125284 Москва, 2-й Боткинский проезд, 3

prognoz.01@mail.ruhttps://orcid.org/0000-0003-2997-4936MarshutinaN. V.МаршутинаН. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

Нина Викторовна Маршутина 

125284 Москва, 2-й Боткинский проезд, 3

nin.mars@mail.ruhttps://orcid.org/0000-0002-5920-5823AlentovI. I.АлентовИ. И.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

Игорь Игоревич Алентов 

125284 Москва, 2-й Боткинский проезд, 3

igor@pushkino.tvKanukoevK. Yu.КанукоевК. Ю.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

Кантемир Юрьевич Канукоев 

125284 Москва, 2-й Боткинский проезд, 3

kan12390@mail.ruhttps://orcid.org/0000-0002-4171-6211NyushkoK. M.НюшкоК. М.

3 2nd Botkinskiy Proezd, Moscow 125284

Кирилл Нюшко Михайлович Нюшко 

125284 Москва, 2-й Боткинский проезд, 3

kirandja@yandex.ruhttps://orcid.org/0000-0002-1353-2271AlekseevB. Ya.АлексеевБ. Я.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

Борис Яковлевич Алексеев 

125284 Москва, 2-й Боткинский проезд, 3

byalekseev@mail.ruhttps://orcid.org/0000-0001-8784-8415KaprinA. D.КапринА. Д.

3 2nd Botkinskiy Proezd, Moscow 125284

Андрей Дмитриевич Каприн 

125284 Москва, 2-й Боткинский проезд, 3

kaprin@mail.ruNational Medical Research Radiological Center, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России300920191531321423004201914062019https://oncourology.abvpress.ru/oncur/article/view/949

The last decades are characterized by an active search for highly sensitive and specific urinological and serological tumor-associated markers of renal cell carcinoma. This review analyses the results of studies of traditional serological tumor-associated markers and a potential new tumor-associated marker of renal cell carcinoma: kidney injury molecule-1, or KIM-1. The structure, sources and functions of KIM-1 in normal conditions and in damaged renal tubules, its potential role in carcinogenesis are described. The experience of using KIM-1 for specifying diagnosis of the most common histological types of renal cell carcinoma is analyzed. Data on KIM-1 expression in malignant tumors in other locations and non-oncological kidney disorders are presented. The role of KIM-1 in early diagnosis of nephrotoxic effect of antitumor drugs is described. The accumulated data is promising in regards to using KIM-1 in clinical oncology as a urinological and serological marker of renal cell carcinoma and chemotherapy nephrotoxicity.

Последние десятилетия активно ведутся поиски высокочувствительных и специфичных уринологических и серологических опухолеассоциированных маркеров (ОМ) для почечно-клеточного рака (ПКР). В обзоре проведен анализ результатов исследования традиционных серологических ОМ и нового потенциального ОМ для ПКР – молекулы повреждения почек-1 (kidney injury molecule-1 - KIM-1). Описаны структура, источники и функции KIM-1 в норме и при повреждении почечных канальцев, его возможная роль в канцерогенезе. Проанализирован опыт использования KIM-1 в уточняющей диагностике наиболее распространенных гистологических типов ПКР. Представлены данные, касающиеся экспрессии KIM-1 при злокачественных новообразованиях других локализаций и при заболеваниях почек неонкологического генеза. Показана роль KIM-1 в ранней диагностике нефротоксичного действия противоопухолевых препаратов. Накопленные данные открывают перспективы использования KIM-1 в клинической онкологии как уринологического и серологического маркера ПКР и нефротоксичности химиотерапии.

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