Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press92310.17650/1726-9776-2019-15-3-126-131REVIEWОБЗОРClinical and morphological features, immune profile of renal cell tumors with clear cytoplasmКлинико-морфологические особенности и иммунный профиль почечно-клеточных опухолей со светлой цитоплазмойhttps://orcid.org/0000-0002-7269-4190OsmanovYu. I.ОсмановЮ. И.
Russian Federation

Anatomic Pathology Department Sechenov First Moscow State Medical University, Ministry of Health of Russia;

Department of Pathology Scientific Clinical Center, Russian Railway

Build. 2, 8 Trubetskaya St., Moscow 119991, 

84 Volokolamskoe Shosse, Moscow 125367

Юсиф Исламович Османов, заведующий отделением патологической анатомии Научного Клинического Центра ОАО РЖД. Доцент кафедры патологической анатомии ГБАОУ ВО Первый МГМУ им.И.М.Сеченова

Москва, 119048, ул.Трубецкая, д.8., стр.1, Москва, 125367, Волоколамское ш., д.84 

osmanovyouseef@yandex.ruhttps://orcid.org/0000-0002-1107-3753KoganE. A.КоганЕ. А.

Anatomic Pathology Department

Build. 2, 8 Trubetskaya St., Moscow 119991

Кафедра патологической анатомии им. акад. А.И. Струкова

Москва, 119048, ул.Трубецкая, д.8., стр.1 

https://orcid.org/0000-0002-4393-8707SeverginaL. O.СевергинаЛ. О.

Anatomic Pathology Department

Build. 2, 8 Trubetskaya St., Moscow 119991

Кафедра патологической анатомии им. акад. А.И. Струкова

Москва, 119048, ул.Трубецкая, д.8., стр.1 

https://orcid.org/0000-0001-7787-1240RapoportL. M.РапопортЛ. М.

84 Volokolamskoe Shosse, Moscow 125367

 

119435 Москва, ул. Большая Пироговская, 2, стр.1

https://orcid.org/0000-0003-2104-5307AleksandrovN. S.АлександровН. С.

Anatomic Pathology Department

Build. 2, 8 Trubetskaya St., Moscow 119991

Кафедра патологической анатомии им. акад. А.И. Струкова

Москва, 119048, ул.Трубецкая, д.8., стр.1 

https://orcid.org/0000-0002-3608-8759TsarichenkoD. G.ЦариченкоД. Г.

84 Volokolamskoe Shosse, Moscow 125367

119435 Москва, ул. Большая Пироговская, 2, стр.1

https://orcid.org/0000-0001-8861-8187KorolyovD. O.КоролёвД. О.

84 Volokolamskoe Shosse, Moscow 125367

119435 Москва, ул. Большая Пироговская, 2, стр.1

Sechenov First Moscow State Medical University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский университет)Scientific Clinical Center, Russian RailwayНаучный клинический центр ОАО «Российские железные дороги»Institute for Urology and Reproductive Health, Sechenov First Moscow State Medical University, Ministry of Health of RussiaНИИ урологии и репродуктивного здоровья человека ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский университет)300920191531261311502201918062019https://oncourology.abvpress.ru/oncur/article/view/923

In the structure of oncological morbidity, renal cell carcinoma takes the 10th place among malignant neoplasms. The increase in incidence is observed from the age of 35–40 years and reaches a maximum at the age of 65–70 years. In terms of frequency of occurrence, clear cell renal cell carcinoma is ranked first among all kidney tumors. Meanwhile, due to the high heterogeneity of renal cell carcinomas with clear cytoplasm group, significant differential diagnostic difficulties arise in the morphological verification of these tumors. The article presents all nosological forms of kidney tumors with clear cytoplasm and provides a database of already known immunohistochemical markers for each nosological unit.

В структуре онкологической заболеваемости почечно-клеточная карцинома занимает 10 место среди злокачественных новообразований. Рост заболеваемости наблюдается с возраста в 35-40 лет и достигает максимума к 65-70 годам. Среди всех опухолей почки светлоклеточная почечно-клеточная карцинома по частоте встречаемости занимает первое место. Между тем, из-за высокой гетерогенности группы почечно-клеточных карцином со светлой цитоплазмой возникают существенные сложности как в морфологической верификации этих новообразований, так и в проведении дифференциальной диагностики. В статье представлена характеристика всех нозологических форм опухолей почки со светлой цитоплазмой, приведены наиболее полные данные по известным базам иммуногистохимических маркеров, адаптированным для каждой конкретной нозологической единицы. 

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