Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press88310.17650/1726-9776-2018-14-3-120-127REVIEWОБЗОРSEQUENTIAL THERAPY OF METASTATIC CASTRATION-RESISTANT PROSTATE CANCER: NEW POSSIBILITIESПОСЛЕДОВАТЕЛЬНАЯ ТЕРАПИЯ МЕТАСТАТИЧЕСКОГО КАСТРАЦИОННО-РЕЗИСТЕНТНОГО РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ: НОВЫЕ ВОЗМОЖНОСТИhttps://orcid.org/0000-0002-3172-2909MarkovaA. S.МарковаА. С.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

Mark-an1@yandex.ruhttps://orcid.org/0000-0001-7748-9527MatveevV. B.МатвеевВ. Б.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

NazranovB. M.НазрановБ. М.
Russian Federation

7 Golovko St., Nalchik 360004, Kabardino-Balkar Republic.

Кабардино-Балкарская республика, 360004 Нальчик, ул. Головко, 7.

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииCity Clinical Hospital No. 1ГБУЗ «Городская клиническая больница № 1»300920181431201270410201804102018https://oncourology.abvpress.ru/oncur/article/view/883

Currently, doctors have at their disposal a number of drugs prolonging life of patients with castration-resistant prostate cancer (CRPC). The majority is approved for use as the 1st line therapy and, in absence of direct comparison, is considered potentially equally effective. Patients with CRPC need continuous treatment for suppression of disease progression resulting in sequential use of therapeutic agents. Modern standards and recommendations do not provide a clear algorithm for prescription, therefore an individual approach is necessary taking in account various factors of a particular case ranging from previous therapies to patients’ preferences. This article considers the most significant factors affecting CRPC therapy selection and ways of therapy optimization in compliance with the established treatment standards and taking into account the list of drugs approved for use in Russia.

В настоящее время в арсенале врача имеется целый ряд лекарственных препаратов, позволяющих увеличить продолжительность жизни больных кастрационно-резистентным раком предстательной железы (КРРПЖ). Большинство из них разрешены для применения в 1-й линии терапии и признаются потенциально равно эффективными ввиду отсутствия их прямого сравнения. Пациенты, страдающие КРРПЖ, нуждаются в непрерывном лечении для сдерживания прогрессирования заболевания, что требует последовательного применения терапевтических агентов. Современные стандарты и рекомендации не дают четкого алгоритма по назначению лечения, поэтому необходим индивидуальный подход в каждом конкретном случае с учетом разнообразных факторов от характера предшествующей терапии до предпочтений пациента. В настоящей статье рассмотрены роль наиболее значимых факторов, влияющих на выбор терапии, и способы оптимизации терапии КРРПЖ в приложении к установленным стандартам лечения и с учетом списка разрешенных в России препаратов.

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