Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press84710.17650/1726-9776-2018-14-2-130-141DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак предстательной железыThe role of taxanes in prostate cancer: literature reviewТаксаны в терапии рака предстательной железы: обзор литературыNorsovA. K.НосовА. К.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Peterburg 197758

Александр Константинович Носов 

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

nakuro@yandex.ruhttps://orcid.org/0000-0001-5183-5153RevaS. A.РеваС. А.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Peterburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

N.N. Petrov Reseach Institute of Oncology, Ministry of Health of RussiaФГБУ «Научно-исследовательский институт онкологии им. Н.Н. Петрова» Минздрава России300620181421301410607201806072018https://oncourology.abvpress.ru/oncur/article/view/847

Prostate cancer is one of the most common causes of death from oncological diseases in men. Taxanes (including docetaxel and cabazitaxel) are microtubule-stabilizing agents which block mitotic cell division leading to apoptosis. Past data have shown promise and good tolerability for different regimens. Recent studies demonstrated that taxanes prolonged the survival both metastatic (hormone sensitive and castrationresistant) locally advanced prostate cancer. In this article, we describe current treatments for рrostate cancer in different stages with taxanes.

Рак предстательной железы — одна из ведущих причин смерти от онкологических заболеваний у мужчин. Нарушение жизненного цикла клетки имеет решающее значение для развития и прогрессирования рака предстательной железы. Таксаны, включая доцетаксел и кабазитаксел, являются стабилизирующими микротрубочки агентами, блокирующими митотическое деление и приводящими к апоптозу. Результаты прошлых исследований показали относительно хорошую переносимость таксанов и многообещающую эффективность в различных режимах применения. В предыдущих работах отмечено увеличение выживаемости пациентов при использовании таксанов при метастатическом (как гормоночувствительном, так и кастрационно-резистентном) и местно-распространенном (в том числе как элемент комбинированного лечения) процессе. В настоящей статье описываются современные подходы к использованию этого класса препаратов в лечении рака предстательной железы на различных стадиях.

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