Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press84610.17650/1726-9776-2018-14-2-68-78DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почкиIndividual approach in choosing second-line targeted therapy for metastatic renal cell carcinomaВозможности индивидуального подхода в выборе 2-й линии таргетной терапии при метастатическом почечно-клеточном ракеhttps://orcid.org/0000-0002-3398-4128AlekseevB. Ya.АлексеевБ. Я.
Russian Federation

32nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

https://orcid.org/0000-0002-6877-0437ShevchukI. M.ШевчукИ. М.
Russian Federation

32nd Botkinskiy Proezd, Moscow 125284

Ирина Мусаевна Шевчук 

125284 Москва, 2-й Боткинский проезд, 3

imshevchuk@mail.ruhttps://orcid.org/0000-0001-8784-8415KaprinA. D.КапринА. Д.
Russian Federation

32nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

National Medical Research Center of Radiology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России3006201814268780507201805072018https://oncourology.abvpress.ru/oncur/article/view/846

Renal cell carcinoma (RCC) is one of the most common genitourinary malignancies worldwide. Approximately 25–30 % of newly diagnosed patients have metastatic RCC (mRCC), whereas in 20–30 % of cases, dissemination occurs after radical surgical treatment. The development of targeted and immunooncological agents in recent years significantly increased survival in patients with mRCC. However, clinicians faced a problem of choosing an optimal therapeutic regimen to achieve maximum effectiveness of the treatment. This article discusses the choice of second-line drugs for mRCC, advantages of axitinib and its optimal dosage, and efficacy of sunitinib depending on the disease prognosis.

Почечно-клеточный рак (ПКР) занимает одно из ведущих мест по заболеваемости в мире среди злокачественных новообразований мочеполовой системы. У 25–30 % больных при первичном обращении диагностируют метастатический ПКР (мПКР), а в 20–30 % случаев диссеминация возникает после радикального хирургического лечения. Благодаря внедрению в онкологическую практику большого числа таргетных и иммуноонкологоческих агентов в последние годы удалось значительно увеличить выживаемость больных мПКР. Однако в настоящее время перед клиницистами стоит проблема выбора лекарственных агентов и определения последовательности их применения для достижения максимальной эффективности каждой линии лечения. В данной статье обсуждаются вопросы выбора препаратов 2-й линии лекарственной терапии мПКР, возможные преимущества использования акситиниба, его оптимальные режимы дозирования, эффективность лечения после приема сунитиниба в зависимости от группы прогноза заболевания.

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