Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press8210.17650/1726-9776-2012-8-1-56-61DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак мочевого пузыряPROGNOSTIC MARKERS OF URINARY BLADDER CANCER RECURRENCE AND LYMPHATIC SPREADМАРКЕРЫ ПРОГНОЗА РЕЦИДИВА И ЛИМФОГЕННОГО МЕТАСТАЗИРОВАНИЯ РАКА МОЧЕВОГО ПУЗЫРЯPavlovV. N.ПавловВ. Н.
Russian Federation
Izmailov75@mail.ruIzmailovA. A.ИзмайловА. А.
Russian Federation
Izmailov75@mail.ruIzmailovaS. M.ИзмайловаС. М.
Russian Federation
Izmailov75@mail.ruUrmancevM. F.УрманцевМ. Ф.
Russian Federation
Izmailov75@mail.ruAhmadishinaL. Z.АхмадишинаЛ. З.
Russian Federation
Izmailov75@mail.ruAlekseevA. V.АлексеевА. В.
Russian Federation
Izmailov75@mail.ruZagitovA. R.ЗагитовА. Р.
Russian Federation
Izmailov75@mail.ruKutliarovL. M.КутлияровЛ. М.
Russian Federation
Izmailov75@mail.ruVictorovaT. V.ВиктороваТ. В.
Russian Federation
Izmailov75@mail.ruState Educational Institution of Higher Professional Education “Bashkirsky Medical State University”, Clinical Hospital Bashkirsky Medical State University,UfaКлиника Башкирского ГМУ, Уфа300320128156612607201426072014https://oncourology.abvpress.ru/oncur/article/view/82

Treatment results (2005-2009) for patients with surface (n = 104) and invasive (n = 104) urinary bladder carcinoma were analyzed. Molecular genetic analysis of cytochrome gene P450 polymorphous locus carried out: CYP1А1 (A2455G), СYP1A2 (T-2464delT), Glutathione S-transferase: GSTM1 (del), GSTP1 (A313G); DNA reparation: XRCC1 (G28152A) for patients with surface urine bladder carcinoma recurrence, which took place within a year, and for patients with surface urine bladder carcinoma without recurrence within a year. Genotypes associated with surface urine bladder carcinoma one-year recurrence were identified. Furthermore, analysis of these genes polymorphous locsus of patients with invasive urine bladder carcinoma with and without lymphogenic metastases was carried out. Genotypes associated with lyphogenic metastasis risk were identified.

Проанализированы результаты лечения пациентов с поверхностным (n = 104) и инвазивным (n = 104) раком мочевого пузыря (РМП) за период с 2005 по 2009 г. Проведен молекулярно-генетический анализ полиморфных локусов генов цитохромов P450: CYP1А1 (A2455G), СYP1A2 (T-2464delT); глутатион-S-трансферазы: GSTM1 (del), GSTP1 (A313G); репарации ДНК: XRCC1 (G28152A) у пациентов с рецидивами поверхностного РМП, возникшими в течение 1 года, и у пациентов с поверхностным РМП без рецидива в течение 1 года. Выявлены генотипы, ассоциированные с появлением рецидива поверхностного РМП в течение 1 года. Кроме того, проведен анализ полиморфных локусов этих генов у пациентов с инвазивным РМП с лимфогенными метастазами и без них. Выявлены генотипы, ассоциированные с риском лимфогенного метастазирования.

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