Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press81010.17650/1726-9776-2018-14-1-107-116DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. PROSTATE CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак предстательной железыMetastatic castration-resistant prostate cancer: a current view on drug therapy and alternative tumor cell regulationМетастатический кастрационно-резистентный рак предстательной железы: современный взгляд на медикаментозную терапию и альтернативная регуляция опухолевых клетокhttps://orcid.org/0000-0002-7592-0392GafanovR. A.ГафановР. А.
Russian Federation

86 Profsoyuznaya St., Moscow 117997

Рустем Айратович Гафанов.

117997 Москва, ул. Профсоюзная, 86

docgra@mail.ruhttps://orcid.org/0000-0003-3851-2581GarmashS. V.ГармашС. В.

Russian Federation

86 Profsoyuznaya St., Moscow 117997

117997 Москва, ул. Профсоюзная, 86

https://orcid.org/0000-0003-1671-369XKravtsovI. B.КравцовИ. Б.
Russian Federation

86 Profsoyuznaya St., Moscow 117997

117997 Москва, ул. Профсоюзная, 86

https://orcid.org/0000-0002-8665-3103FastovetsS. V.ФастовецС. В.
Russian Federation

86 Profsoyuznaya St., Moscow 117997

117997 Москва, ул. Профсоюзная, 86

Russian Scientific Center of Roentgen Radiology, Ministry of Health of RussiaФГБУ «Российский научный центр рентгенорадиологии» Минздрава России300320181411071161204201812042018https://oncourology.abvpress.ru/oncur/article/view/810

Prostate cancer (PC) is one of the most common causes of death from malignant neoplasms in men in many countries around the world. Transmission of the signal in the androgenic axis of regulation is crucial for the development and progression of PC. Despite the constant dependence on androgen receptor signals in castration resistance, the use of new anti-androgenic drugs invariably leads to the stability  of the ongoing treatment. The interaction of androgen receptor and alternative (phosphoinositide-3-kinases, PI3K) pathways in the regulation of cells can be one of the mechanisms of resistance to treatment. In this article, we describe current treatments for metastatic castration-resistant PC and the possible role of the PI3K pathway in the pathogenesis and progression of PC.

Рак предстательной железы (РПЖ) является одной из самых частых причин смерти от злокачественных новообразований у мужчин во многих странах мира. Передача сигнала в андрогенной оси регуляции имеет решающее значение для развития и прогрессирования РПЖ. Несмотря на постоянную зависимость от сигналов андрогенных рецепторов при кастрационной резистентности, использование новых антиандрогенных препаратов неизменно приводит к развитию резистентности к лечению. Взаимодействие андрогенрецепторного и альтернативного (фосфатидилинозитол-3-киназа, PI3K) путей в регуляции опухолевых клеток может быть одним из механизмов развития резистентности к терапии. В настоящей статье описываются современные методы лечения метастатического кастрационно-резистентного РПЖ и возможная роль пути PI3K в патогенезе и прогрессировании РПЖ.

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