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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">688</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2017-13-2-56-62</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почки</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Targeted therapy of advanced renal cell carcinoma</article-title><trans-title-group xml:lang="ru"><trans-title>Таргетная терапия распространенного почечно-клеточного рака</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>15 Marshala Timoshenko St., Moscow 121359</italic></p></bio><bio xml:lang="ru"><p>Александр Михайлович Попов </p><p><italic>121359 Москва, ул. Маршала Тимошенко, 15 </italic></p></bio><email>palexdoc@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central Clinical Hospital, Administration of the President of the Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента Российской Федерации</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2017</year></pub-date><volume>13</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>56</fpage><lpage>62</lpage><history><date date-type="received" iso-8601-date="2017-06-19"><day>19</day><month>06</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-06-19"><day>19</day><month>06</month><year>2017</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/688">https://oncourology.abvpress.ru/oncur/article/view/688</self-uri><abstract xml:lang="en"><p>The standard method of treatment of patients with metastatic renal cell carcinoma is targeted therapy. Selection of drugs for these patients has remained a complex task. In the absence of predictors of effectiveness, clinical trials should serve as a reference point. </p></abstract><trans-abstract xml:lang="ru"><p>Стандартным методом лечения пациентов, страдающих метастатическим почечно-клеточным раком, является таргетная терапия. Выбор препаратов для таких больных остается сложной задачей. В отсутствие предикторов эффективности следует ориентироваться на результаты клинических исследований. </p></trans-abstract><kwd-group xml:lang="en"><kwd>kidney cancer</kwd><kwd>targeted therapy</kwd><kwd>lenvatinib</kwd><kwd>nivolumab</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак почки</kwd><kwd>таргетная терапия</kwd><kwd>ленватиниб</kwd><kwd>ниволумаб</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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