Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press68710.17650/1726-9776-2017-13-2-49-55DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почкиTargeted therapy in patients with poor-prognosis renal cell carcinomaТаргетная терапия больных метастатическим раком почки неблагоприятного прогнозаAlekseevB. Ya.АлексеевБ. Я.
Russian Federation
KalpinskiyA. S.КалпинскийА. С.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

Алексей Сергеевич Калпинский 

125284 Москва, 2-й Боткинский проезд, 3 

dr.Kalpinskiy@rambler.ruMukhomed’yarovaA. A.МухомедьяроваА. А.
Russian Federation
NyushkoK. M.НюшкоК. М.
Russian Federation
KaprinA. D.КапринА. Д.
Russian Federation
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава России3006201713249551906201719062017https://oncourology.abvpress.ru/oncur/article/view/687

The majority of patients with metastatic renal cell carcinoma (mRCC) are in the groups of favorable or moderate prognosis per the MSKCC (MemorialSloan-KetteringCancerCenter) criteria, but in 20–30 % of poor-prognosis patients aggressive, rapidly progressing mRCC is observed. Despite improved prognosis in mRCC patients due to targeted therapy, this patient group remains hard to treat with overall survival 6 months) was higher in the temsirolimus (32.1 %) and combination (28.1 %) groups compared to the IFN-α group (15.5 %; р<0,001).

Большинство больных метастатическим почечно-клеточным раком (мПКР) относятся к группе благоприятного и промежуточного прогноза согласно критериям шкалы MSKCC (Memorial Sloan-Kettering Cancer Center), однако у 20–30 % пациентов с неблагоприятным прогнозом регистрируется агрессивный, быстро прогрессирующий мПКР. Несмотря на улучшение прогноза заболевания у больных мПКР на фоне таргетной терапии, эта категория пациентов остается трудно поддающейся лечению, а показатели общей выживаемости составляют 6 мес) оказалась выше в группах темсиролимуса (32,1 %) и комбинированного лечения (28,1 %), чем в группе ИФН-α (15,5 %; р<0,001). 

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