Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press56810.17650/1726-9776-2016-12-3-102-108CLINICAL CASEКЛИНИЧЕСКИЙ СЛУЧАЙMalignant paraganglioma of the urinary bladder. Description of clinical casesЗлокачественная параганглиома мочевого пузыря. Описание клинических случаевKhaylenkoA. V.ХайленкоА. В.
Russian Federation

24 Kashirskoye shosse, Moscow, 115478

Department of Oncology the Faculty of Additional Professional Education

1 Ostrovityanova St., Moscow, 117997

115478, Москва, Каширское шоссе, 24

кафедра онкологии факультета дополнительного профессионального образования 

117997, Москва, ул. Островитянова, 1 

a.khaylenko@mail.ruFigurinK. M.ФигуринК. М.
Russian Federation

24 Kashirskoye shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 24

Профессор урологического отделения РОНЦ им.Н.Н.Блохина

kfigurin@MAIL.RUKazantsevA. P.КазанцевА. П.
Russian Federation

24 Kashirskoye shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 24

RybakovaD. V.РыбаковаД. В.
Russian Federation

24 Kashirskoye shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 24

PerevoshchikovA. G.ПеревощиковА. Г.
Russian Federation

24 Kashirskoye shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 24

профессор отделения патологической анатомии опухолей человека РОНЦ им.Н.Н.Блохина

a.khaylenko@mail.ruRomanovaK. A.РомановаК. А.
Russian Federation

24 Kashirskoye shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 24

Federal State Budgetary Institution «Russian oncological Research Center named after N.N. Blokhin» of the Russian Ministry of HealthФГБУ «РОНЦ им. Н.Н. Блохина» Минздрава РоссииN.I. Pirogov Russian National Research Medical University at the Ministry of Health of RussiaФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России300920161231021080906201614072016https://oncourology.abvpress.ru/oncur/article/view/568

Paraganglioma is hormonally active tumor originating from chromaffin tissue of sympathoadrenal system that secrete large amounts of catecholamines. Paraganglioma of the urinary bladder is a rare neoplasm, constituting approximately 0.06 % of all tumors of this localization. It is believed that this disease arises from embryonic remnants of chromaffin cells in the sympathetic plexus of the detrusor. Up to 10 % of these tumors have malignant origin. Diagnosis and tactics of treatment of patients with malignant paragangliomas of the bladder presents certain difficulties. The article describes 2 clinical observations of patients with this bladder pathology. 

Паганглиома — гормонально-активная опухоль, исходящая из хромаффинной ткани симпатоадреналовой системы, секретирующая большое количество катехоламинов. Как правило, данные опухоли развиваются в мозговом веществе надпочечников и называются феохромоцитомами. Около 10% от всех феохромоцитом развиваются вне надпочечников. Данные новообразования называются параганглиомами. Вненадпочечниковые феохромоцитомы (параганглиомы) обычно локализуются параортально, исходя из ганглиев симпатической нервной системы. Параганглиома мочевого пузыря встречается редко и составляет примерно 0,06% от всех новообразований мочевого пузыря и около 10% от всех параганглиом.[1,2,3,4]. Считается, что данное заболевание возникает из эмбриональных остатков хромафинных клеток в симпатическом сплетении детрузора [5].

В 1953 году Зимерман и др. впервые описали в научной литературе клиническое наблюдение параганглиомы мочевого пузыря. С того времени в мировой литературе описывалось около 250 случаев феохромоцитомы мочевого пузыря, около 10% из этих опухолей определялись метастазы в тазовые лимфоузлы, то есть около  25 случаев относилось к злокачественным параганглиомам мочевого пузыря. [3,6,7,8,9]. Признаки «злокачественности» данных опухолей могут проявляться в появлении отдаленных или регионарных метастазов. В настоящее время не существует надежных гистологических признаков отличающих злокачественные от доброкачественных параганглиом.

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