Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press56310.17650/1726-9776-2016-12-3-30-39DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почкиResults and analysis of the application of a consistent targeted therapy in patients with metastatic renal cell carcinoma in Moscow (for the period from June 2005 to July 2015)Результаты и анализ применения последовательной таргетной терапии ингибиторами тирозинкиназ у больных метастатическим почечно-клеточным раком в Москве (за период с июня 2005 г. по июль 2015 г.)ShirokoradV. I.ШирокорадВ. И.
Russian Federation

27 Istra Settlement, Moscow Region, 143423

143423, Московская область, пос. Истра, 27

Shirokorad@bk.ruKolesnikovG. P.КолесниковГ. П.
Russian Federation

27 Istra Settlement, Moscow Region, 143423

143423, Московская область, пос. Истра, 27

KostritskiyS. V.КострицкийС. В.
Russian Federation

27 Istra Settlement, Moscow Region, 143423

143423, Московская область, пос. Истра, 27

врач-онколог онкоурологического отделения Московской онкологической больницы №62

Stas.medic@bk.ruKashintsevK. Yu.КашинцевК. Ю.
Russian Federation

27 Istra Settlement, Moscow Region, 143423

143423, Московская область, пос. Истра, 27

DolgikhD. V.ДолгихД. В.
Russian Federation

27 Istra Settlement, Moscow Region, 143423

143423, Московская область, пос. Истра, 27

Moscow City Cancer Hospital No 62, Moscow Healthcare DepartmentГАУЗ г. Москвы «Московская городская онкологическая больница № 62 Департамента здравоохранения г. Москвы»3009201612330392604201623072016https://oncourology.abvpress.ru/oncur/article/view/563

Background. This article is a personal experience of a sequential targeted therapy of tyrosine kinase inhibitors for the period from June 2005 to July 2015.

Objective: evaluation of the results of the consistent application of targeted therapies in Moscow in this period.

Materials and methods. A retrospective analysis of cumulative progression-free survival in 220 patients of 354 patients with mRCC were studied. Was used Statistica 10.0 program.

Results. This article presents an analysis of the effectiveness of treatment and survival of patients receiving this therapy in cancer institutions Department of Health in Moscow.

Conclusion. Using of targeted therapy scheme sunitinib → sorafenib, we see no significant difference sVBP compared with scheme sorafenib → sunitinib with two lines ofsequential therapy tyrosine kinase inhibitors (16.9 and 18.2 months). According to our data total progression-free survival terms as applied to the 1st line of therapy tirosine kinase inhibitors (sunitinib and sorafenib), followed by the appointment pazopanib in the 2nd line (12.5 and 14.4 months) and pazopanib in 1st line followed by the appointment tirazinkinaz inhibitors (sunitinib and sorafenib) in the 2nd line (12.50 and 11.56 months) compared to the preliminary results of a multicenter randomized trial expected SWITCH II also not statistically different. 

В данной статье приведен собственный опыт применения последовательной таргетной терапии ингибиторами тирозинкиназ за период с июня 2005 г. по июль  2015 г.  Проведена сравнительная оценка применения последовательной терапии таргетными агентами у 354 пациентов мПКР,  и представлен промежуточный результат, анализ выживаемости и эффективности лечения больных, получавших данную терапию в онкологических учреждениях Департамента здравоохранения г. Москвы. 

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