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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">521</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2015-11-4-24-33</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCER</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почки</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Current treatment approach to non-clear cell renal carcinoma</article-title><trans-title-group xml:lang="ru"><trans-title>Современные возможности лечения несветлоклеточного почечно-клеточного рака</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tsimafeyeu</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Тимофеев</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Kidney Cancer Research Bureau,</p><p>2 Mayakovskogo pereulok, Moscow, 109147</p></bio><bio xml:lang="ru"><p>Бюро по изучению рака почки, </p><p>109147, Москва, пер. Маяковского, 2</p></bio><email>office@kidneytumor.org</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian society of clinical oncology</institution></aff><aff><institution xml:lang="ru">Российское общество клинической онкологии</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-12-30" publication-format="electronic"><day>30</day><month>12</month><year>2015</year></pub-date><volume>11</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>24</fpage><lpage>33</lpage><history><date date-type="received" iso-8601-date="2015-12-10"><day>10</day><month>12</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-12-10"><day>10</day><month>12</month><year>2015</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/521">https://oncourology.abvpress.ru/oncur/article/view/521</self-uri><abstract xml:lang="en"><p>Non-clear cell renal cell carcinoma has various histologic subtypes. Tumor biology plays significant role in the disease development. However, despite the one surgical approach both to clear cell and non-clear cell renal carcinoma, patients’ outcomes within one stage of the disease may vary. Furthermore, tumor sensitivity and its response to therapy are highly dependent on the same histologic subtype.</p><p>The article gives detailed data on the current treatment of papillary, chromophobe and other histologic subtypes of renal cell carcinoma.</p></abstract><trans-abstract xml:lang="ru"><p>Несветлоклеточный почечно-клеточный рак представлен несколькими гистологическими вариантами. Биология опухоли существенно влияет на течение заболевания. Несмотря на единство хирургического лечения светлоклеточного и несветлоклеточного рака почки, прогноз пациентов с формально одинаковыми стадиями может отличаться. Чувствительность опухоли к лекарственной терапии также зависит от гистологического подтипа. В статье подробно рассматриваются современные возможности лечения папиллярного, хромофобного и других видов почечно-клеточного рака.</p></trans-abstract><kwd-group xml:lang="en"><kwd>non-clear cell renal cell carcinoma</kwd><kwd>classification</kwd><kwd>prognosis</kwd><kwd>surgery</kwd><kwd>targeted therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>несветлоклеточный почечно-клеточный рак</kwd><kwd>классификация</kwd><kwd>прогноз</kwd><kwd>хирургическое лечение</kwd><kwd>таргетная терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Алексеев Б.Я., Анжиганова Ю.В., Лыков А.В. и др. Особенности диагностики и лечения рака почки в России: предварительные результаты многоцентрового кооперированного исследования. Онкоурология 2012;(3):24–30. [Alekseyev B.Ya., Anzhiganova Yu.V., Lykov A.V. et al. 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