Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press510.17650/1726-9776-2014-10-1-10-15DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почкиCLINICAL VALUE OF THE MARKERS OF PROLIFERATION AND APOPTOSIS IN PATIENTS WITH CLEAR CELL RENAL CELL CARCINOMAКЛИНИЧЕСКОЕ ЗНАЧЕНИЕ МАРКЕРОВ ПРОЛИФЕРАЦИИ И АПОПТОЗА У БОЛЬНЫХ СВЕТЛОКЛЕТОЧНЫМ ПОЧЕЧНО-КЛЕТОЧНЫМ РАКОМGorbanN. A.ГорбаньН. А.
Russian Federation
perovanina@mail.ruIvanovaS. V.ИвановС. В.
Russian Federation
perovanina@mail.ruKaryakinO. B.КарякинО. Б.
Russian Federation
perovanina@mail.ruPopovA. M.ПопоА. М.
Russian Federation
perovanina@mail.ruVarlamovS. A.ВарламовС. А.
Russian Federation
perovanina@mail.ruGanovD. I.ГановД. И.
Russian Federation
perovanina@mail.ruMedical Radiology Research Center, Ministry of Health of Russia, ObninskФГБУ МРНЦ Минздрава России, ОбнинскAltai Territory Oncology Dispensary, BarnaulКГБУЗ «Алтайский краевой онкологический диспансер», Барнаул3003201410110152407201424072014https://oncourology.abvpress.ru/oncur/article/view/5

Renal cell carcinoma (RCC) is a heterogeneous disease in which the patients survive for months to years. At the present time the prognostic models have no sufficient information or exact prognostic value. Cell proliferation and apoptosis play a key role in cell cycle regulation; and impairment in these processes is commonly detected in different human tumors. The investigation enrolled 76 patients (49 men, 27 women) aged 32 to 73 years (mean age 56 ± 7.6 years) diagnosed with RCC. The follow-up was 8 to 116 months (mean 36.5 months). All the patients underwent nephrectomy; antibodies against р53, Bcl-2, and Ki-67 were investigated by immunohistochemistry. The expression of p53 and none or reduced expression of Bcl-2 are poor prognostic factors and associated with the metastatic potential of a tumor and with low relapse-free survival. High Ki-67 levels are a risk factor for metastases. A combination of p53 expression and high proliferative activity reflects the aggressive potential of a tumor and suggests the high risk of metastases just at the disease diagnosis and early tumor dissemination.

 

Почечно-клеточный рак (ПКР) – гетерогенное заболевание, при котором пациенты живут от нескольких месяцев до нескольких лет. В настоящее время прогностические модели не обладают достаточной информативностью и точной прогностической ценностью. Клеточная пролиферация и апоптоз играют ключевую роль в регуляции клеточного цикла, и нарушение этих процессов часто выявляется при различных опухолях человека. В исследование были включены 76 пациентов (49 мужчин и 27 женщин) в возрасте от 32 до 73 лет, средний возраст 56 ± 7,6 года с диагнозом ПКР. Срок наблюдения составил от 8 до 116 мес (средний срок – 36,5 мес). Всем больным была выполнена нефрэктомия, проведено иммуногистохимическое исследование с антителами к р53, Bcl-2 и Ki-67. Экспрессия р53 и отсутствие экспрессии или редуцированная экспрессия Bcl-2 являются факторами небла-гоприятного прогноза, связаны с метастатическим потенциалом опухоли и низкой безрецидивной выживаемостью. Высокий уровень Ki-67 – фактор риска развития метастазов. А сочетание экспрессии р53 и высокой пролиферативной активности отражает агрессивный потенциал опухоли и свидетельствует о высоком риске метастазов уже на момент диагностики заболевания или ранней диссеминации опухоли.

 

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