Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press49710.17650/1726-9776-2015-11-3-108-116REVIEWОБЗОРChemotherapy in the treatment of metastatic prostate cancer: the present state of the problemХимиотерапия в лечении больных метастатическим раком предстательной железы: современное состояние проблемыAlekseevB. Ya.АлексеевБ. Я.
Russian Federation
byalekseev@mail.ruN.А. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationНИИ урологии и интервенционной радиологии им. Н.А. Лопаткина – филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава России4 Bldg, 51, 3erd Parkovaya St., Moscow, 105425, RussiaРоссия, 105425, Москва, ул. 3-я Парковая, 51300920151131081162409201524092015https://oncourology.abvpress.ru/oncur/article/view/497

The paper reviews the current possibilities of cytostatic chemotherapy in patients with metastatic prostate cancer. It gives the data of studies dealing with the early use of docetaxel in patents with hormone-susceptible tumors and analyzes approaches to sequential therapy with docetaxel, cabazitaxel, and antiandrogens (abiraterone, enzalutamide) in patients with castration-refractory prostate cancer. Assessment of the prognostic role of different clinical and biological factors could provide an algorithm for the choice of first- and second-line therapy in patients with castration resistance.

В статье приведен обзор современных возможностей цитостатической химиотерапии у больных метастатическим раком предстательной железы. Представлены данные исследований по раннему назначению доцетаксела у больных с гормонально чувствительными опухолями, проанализированы подходы к последовательной терапии доцетакселом, кабазитакселом и антиандрогенными препаратами (абиратерон, энзалутамид) у больных кастрационно-резистентным раком предстательной железы. На основании оценки прогностической роли различных клинических и биологических факторов представлен алгоритм выбора терапии 1-й и 2-й линии у пациентов с кастрационной резистентностью.

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