Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press49010.17650/1726-9776-2015-11-3-62-70DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак мочевого пузыряRole of the FGFR3 gene mutation status in predicting progression of non-muscle-invasive bladder cancerРоль мутационного статуса гена FGFR3 в предсказании прогрессирования рака мочевого пузыря без мышечной инвазииRolevichA. I.РолевичА. И.
Russian Federation
alexander.rolevich@gmail.comSmalM. P.СмальМ. П.
Russian Federation
KrasnyiS. A.КрасныйС. А.
Russian Federation
GoncharovaR. I.ГончароваР. И.
Russian Federation
N. N. Aleksandrov Republican Research and Practical Center for Oncology and Medical RadiologyГУ «Республиканский научно-практический центр онкологии и медицинской радиологии им. Н. Н. Александрова»Lesnoy Settlement, Minsk District, 223040, BelarusРеспублика Беларусь, 223040, Минский район, пос. ЛеснойInstitute of Genetics and Cytology, National Academy of Sciences of BelarusИнститут генетики и цитологии Национальной академии наук Беларуси27, Akademicheskaya St., Minsk 220072, BelarusРеспублика Беларусь, 220072, Минск, ул. Академическая, 273009201511362702409201524092015https://oncourology.abvpress.ru/oncur/article/view/490

A prospective study was conducted to assess the prognostic value of FGFR3 gene mutation status in patients with non-muscle invasive bladder cancer. A total of 265 patients were included in the study. FGFR3 gene mutations were found in 168 (63.4 %) cases. FGFR3 mutation rate was significantly higher in low-grade tumors (p = 0.00 004). With a median follow-up of 34 months hazard ratio of progression in FGFR3 mutant cases compared to FGFR3 wild type was 0.50 (95 % CI 0.17–1.49; p = 0.21). In the subgroup analysis, it was found that FGFR3 mutations in patients with T1 high grade tumors (n = 41) were associated with a significantly better prognosis: 3-year progression-free survival (PFS) in FGFR3 mutant cases (n = 17) was 100 % compared to 71.2 % (95 % CI 42.8–99.6 %) in the absence of mutations (n = 24). For other subgroups (Ta, T1 low grade) no statistically significant difference in PFS by FGFR3 mutation status was noted.

Проведено проспективное исследование по оценке прогностического значения мутационного статуса гена FGFR3 у пациентов с раком мочевого пузыря без мышечной инвазии. В исследование включено 265 пациентов, у 168 (63,4 %) обнаружены мутации гена FGFR3. Установлено, что частота мутаций гена FGFR3 была статистически значимо выше в высокодифференцированных опухолях (р = 0,00004). При медиане наблюдения 34 мес не выявлено статистически значимого показателя относительного риска прогрессирования рака мочевого пузыря без мышечной инвазии при наличии мутации гена FGFR3 по сравнению с ее отсутствием (0,50; 95 % доверительный интервал (ДИ) 0,17–1,49; p = 0,21). При анализе прогностического значения мутационной изменчивости гена FGFR3 в различных подгруппах было обнаружено, что у пациентов с опухолями T1 high grade (n = 41) мутации гена FGFR3 были связаны со статистически значимо лучшим прогнозом: 3-летняя выживаемость до прогрессирования при наличии мутации (n = 17) составила 100 % по сравнению с 71,2 % (95 % ДИ 42,8–99,6 %) при отсутствии мутации (n = 24). При остальных категориях опухолей (Ta, T1 low grade) статистически значимых различий в выживаемости до прогрессирования в зависимости от мутационного статуса FGFR3 не выявлено.

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