Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press48510.17650/1726-9776-2015-11-3-34-39DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫRole of markers for acute kidney injury in surgical management of patients with renal cancerРоль маркеров острого повреждения почек в выборе тактики хирургического лечения больных раком почкиKitO. I.КитО. И.
Russian Federation
FrantsiyantsE. M.ФранциянцЕ. М.
Russian Federation
DimitriadiS. N.ДимитриадиС. Н.
Russian Federation
dimitriadi@yandex.ruKaplievaI. V.КаплиеваИ. В.
Russian Federation
TrepitakiL. K.ТрепитакиЛ. К.
Russian Federation
CheryarinaN. D.ЧеряринаН. Д.
Russian Federation
PogorelovaYu. A.ПогореловаЮ. А.
Russian Federation
Rostov Cancer Research Institute, Ministry of Health of RussiaГФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России63, Fourteenth Line, Rostov-on-Don 344037, RussiaРоссия, 344037, Ростов-на-Дону, ул. 14-я линия, 633009201511334392309201523092015https://oncourology.abvpress.ru/oncur/article/view/485

The paper gives the results of studying the urinary levels of markers of acute kidney injury (AKI) in 46 patients with renal cancer during separate ureteral catheterization before the surgery and 24 hours after laparoscopic partial nephrectomy performed due to elective indications under warm ischemia. The levels of cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), and interleukin-18 were examined by enzyme immunoassay. It has been established that the risk of early postoperative AKI may be predicted from the baseline urinary levels of cystatin C and LFABP in patients with renal cancer resulting from 15-20-min warm ischemia time during the partial nephrectomy. An approach based on estimation of the baseline urinary levels of cystatin C and L-FABP to be incorporated into a preoperative examination scheme is proposed for surgical treatment policy choosing in patients with renal cancer. A scheme for examining patients with renal cancer is also suggested for the risk of complications and the degree of AKI assessing in the early post-operative period.

статье представлены результаты изучения уровней маркеров острого повреждения почек (ОПП) в моче 46 больных раком почки (РП), забранной при помощи раздельной катетеризации мочеточников до этапа лапароскопической резекции почки, выполненной по элективным показаниям в условиях тепловой ишемии, и через сутки после оперативного лечения. Исследование уровней цистатина С, NGAL, L-FABP и интерлейкина 18 проводили методом иммуноферментного анализа. Установлено, что по исходному уровню цистатина С и L-FABP в моче возможно прогнозировать у больных РП риск развития ОПП в раннем послеоперационном периоде, возникающего вследствие тепловой ишемии (продолжительностью 15–20 мин) при резекции почки. Предложен подход к выбору тактики хирургического лечения больных РП, основанный на включении в схему предоперационного обследования оценки исходного уровня цистатина С и L-FABP в моче. Также предложена схема обследования больных РП на предмет риска развития осложнений и степени ОПП в раннем послеоперационном периоде.

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