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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">41</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2010-6-2-8-13</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Practical recommendations for the prevention and correction of adverse reactions of sunitinib</article-title><trans-title-group xml:lang="ru"><trans-title>ПРАКТИЧЕСКИЕ РЕКОМЕНДАЦИИ ПО ПРЕДОТВРАЩЕНИЮ И КОРРЕКЦИИ ПОБОЧНЫХ ЭФФЕКТОВ СУНИТИНИБА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gutorov</surname><given-names>S. L.</given-names></name><name xml:lang="ru"><surname>Гуторов</surname><given-names>С. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>s1gutorov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Borisova</surname><given-names>E. I.</given-names></name><name xml:lang="ru"><surname>Борисова</surname><given-names>Е. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>s1gutorov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2010</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>8</fpage><lpage>13</lpage><history><date date-type="received" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/41">https://oncourology.abvpress.ru/oncur/article/view/41</self-uri><abstract xml:lang="en"><p>At present Sunitinib is the drug of choice in the treatment of metastatic renal cell carcinoma. In some cases complications due to the use of the drug make it to be unreasonably discontinued, which potentially affects the results of therapy. The paper proposes practical recommendations for the prevention, timely detection, and correction of the adverse reactions of Sunitinib, which enables the treatment to be performed safely and in adequate doses.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящее время cунитиниб является опцией эффективного лечения метастатического рака почки. В ряде случаев осложнения на фоне приема препарата приводят к необоснованной его отмене, что потенциально отражается на результатах терапии. В статье предложены практические рекомендации по предотвращению, своевременному выявлению и выбору методов коррекции побочных эффектов cунитиниба, позволяющие проводить лечение безопасно и в адекватных дозах.</p></trans-abstract><kwd-group xml:lang="en"><kwd>sunitinib</kwd><kwd>metastatic renal cell carcinoma</kwd><kwd>complications</kwd><kwd>correction methods</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>cунитиниб</kwd><kwd>метастатический рак почки</kwd><kwd>осложнения</kwd><kwd>методы коррекции</kwd></kwd-group><funding-group><funding-statement xml:lang="en">sunitinib; metastatic renal cell carcinoma; complications; correction methods</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Motzer R.J., Hutson T.E., Tomczak P. et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. 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