Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press37110.17650/1726-9776-2010-6-4-92-101CLINICAL CASEКЛИНИЧЕСКИЙ СЛУЧАЙHUMAN PAPILLOMAVIRUS AS A RISK FACTOR FOR BLADDER CANCERВИРУС ПАПИЛЛОМЫ ЧЕЛОВЕКА КАК ФАКТОР РИСКА ПРИ РАКЕ МОЧЕВОГО ПУЗЫРЯVolgarevaG. M.ВолгареваГ. М.
Russian Federation
gmvolgareva@front.ruFrankG. A.ФранкГ. А.
Russian Federation
gmvolgareva@front.ruGolovinaD. A.ГоловинаД. А.
Russian Federation
gmvolgareva@front.ruZavalishinaL. E.ЗавалишинаЛ. Э.
Russian Federation
gmvolgareva@front.ruAndreyevaYu. Yu.АндрееваЮ. Ю.
Russian Federation
gmvolgareva@front.ruKhachaturyanA. V.ХачатурянА. В.
Russian Federation
gmvolgareva@front.ruChebanN. L.ЧебанН. Л.
Russian Federation
gmvolgareva@front.ruMatveevV. B.МатвеевВ. Б.
Russian Federation
gmvolgareva@front.ruResearch Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, RussianНИИ канцерогенеза РОНЦ им. Н.Н. Блохина РАМНDepartment of Human Pathology, P.A. Herzen Moscow Research Oncological InstituteОтделение патологической анатомии ФГУ МНИОИ им. П.А. ГерценаResearch Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowНИИ клинической онкологии РОНЦ им. Н.Н. Блохина РАМН, Москва3012201064921012509201425092014https://oncourology.abvpress.ru/oncur/article/view/371

The paper reviews the data available in the literature on the possible involvement of human papillomavirus in the induction of bladder cancer (BC). The results of the authors studies in this area are summarized. The data obtained in clinical and experimental studies in vivo and in vitro count in favor of the idea that human papillomavirus may be implicated in the genesis of BC.

Представлен обзор литературы по проблеме возможного участия вируса папилломы человека в индукции рака мочевого пузыря (РМП). Суммированы результаты собственных исследований в этой области. Данные, полученные на клиническом материале и экспериментальных моделях in vivo и in vitro, свидетельствуют в пользу точки зрения, согласно которой вирус папилломы человека может участвовать в генезе РМП.

bladder cancerhuman papillomavirusрак мочевого пузырявирус папилломы человека1. Zur Hauzen H. Papillomaviruses causing cancer: evasiom from host-cell control in early events in arcinogenesis. J Natl Cancer Inst 2000;92:690−8.Zur Hauzen H. Papillomaviruses causing cancer: evasiom from host-cell control in early events in arcinogenesis. J Natl Cancer Inst 2000;92:690−8.2. Zur Hauzen H. Papillomaviruses – to vaccination and beyond. Biochemistry 2008;73(5):498−505.Zur Hauzen H. Papillomaviruses – to vaccination and beyond. Biochemistry 2008;73(5):498−505.3. IARC monographs on the evaluation of carcinogenic risks to humans. Human papillomaviruses. Lyon, 2007. Available from: http://monographs.iarc.fr/ENG/Monographs/vol90/index.phpIARC monographs on the evaluation of carcinogenic risks to humans. Human papillomaviruses. Lyon, 2007. Available from: http://monographs.iarc.fr/ENG/Monographs/vol90/index.php4. Morrison C., Catania F., Wakely P. Jr., Nuovo G.J. Highly differentiated keratinizing squamous cell cancer of the cervix. A rare, locally aggressive tumor not associated with human papillomavirus or squamous intraepithelial lesions. Am J Surg Path 2001;25:1310−5.Morrison C., Catania F., Wakely P. Jr., Nuovo G.J. Highly differentiated keratinizing squamous cell cancer of the cervix. A rare, locally aggressive tumor not associated with human papillomavirus or squamous intraepithelial lesions. Am J Surg Path 2001;25:1310−5.5. Gillison M.L., Shah K.V. Role of mucosal human papillomavirus in nongenital cancers. J Natl Cancer Inst Monograph 2003;31(9):57−65.Gillison M.L., Shah K.V. Role of mucosal human papillomavirus in nongenital cancers. J Natl Cancer Inst Monograph 2003;31(9):57−65.6. Волгарева Г.М., Завалишина Л.Э., Андреева Ю.Ю. и др. Гиперэкспрессия клеточного белка p16INK4a в эпителиальных злокачественных опухолях, индуцированных вирусами папиллом человека. Обзор. Арх патол 2008;70(5):57−61.Волгарева Г.М., Завалишина Л.Э., Андреева Ю.Ю. и др. Гиперэкспрессия клеточного белка p16INK4a в эпителиальных злокачественных опухолях, индуцированных вирусами папиллом человека. Обзор. Арх патол 2008;70(5):57−61.7. Klaes R., Fridrich T., Spitkovsky D.et al. Overexpression of p16 (INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001;92:276−84.Klaes R., Fridrich T., Spitkovsky D.et al. Overexpression of p16 (INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001;92:276−84.8. Volgareva G., Zavalishina L., Andreeva Y.et al. Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells. BMC Cancer, 2004. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517716/Volgareva G., Zavalishina L., Andreeva Y.et al. Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells. BMC Cancer, 2004. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517716/9. Begum S., Gillison M.L., Nikol T.L., Westra W.H. Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 2007;13(4):1186−91.Begum S., Gillison M.L., Nikol T.L., Westra W.H. Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 2007;13(4):1186−91.10. Kim S.H., Koo B.S., Kang S. et al. HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. Int J Cancer 2007;120:1418−25.Kim S.H., Koo B.S., Kang S. et al. HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. Int J Cancer 2007;120:1418−25.11. Parkin D.M., Whelan S.L., Ferlay J. et al. Cancer incidence in five continents. Vol. VIII. Lyon: IARC Press, 2002; p.705−71.Parkin D.M., Whelan S.L., Ferlay J. et al. Cancer incidence in five continents. Vol. VIII. Lyon: IARC Press, 2002; p.705−71.12. Litlekalsoy J., Vatne V., Hostmark J.G., Laerum O.D. Immunohistochemical markers in urinary bladder carcinomas from paraffinembedded archival tissue after storage for 5−70 years. Br J Urol Int 2007;99:1013−9.Litlekalsoy J., Vatne V., Hostmark J.G., Laerum O.D. Immunohistochemical markers in urinary bladder carcinomas from paraffinembedded archival tissue after storage for 5−70 years. Br J Urol Int 2007;99:1013−9.13. Злокачественные новообразования в России в 2007 г. (заболеваемость и смертность). Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М., 2009.Злокачественные новообразования в России в 2007 г. (заболеваемость и смертность). Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М., 2009.14. Заридзе Д.Г., Некрасова Л.И.,Басиева Т.Х. Факторы повышенного риска возникновения рака мочевого пузыря. Вопр онкол 1992;38(7−9):1066−73.Заридзе Д.Г., Некрасова Л.И.,Басиева Т.Х. Факторы повышенного риска возникновения рака мочевого пузыря. Вопр онкол 1992;38(7−9):1066−73.15. Заридзе Д.Г. Эпидемиология и этиология злокачественных новообразований. Канцерогенез. Руководство. М.: Медицина,2004; с. 29−85.Заридзе Д.Г. Эпидемиология и этиология злокачественных новообразований. Канцерогенез. Руководство. М.: Медицина,2004; с. 29−85.16. Заридзе Д.Г. Профилактика рака. М.:ИМА-ПРЕСС, 2009.Заридзе Д.Г. Профилактика рака. М.:ИМА-ПРЕСС, 2009.17. Матвеев Б.П. Статистика, эпидемиология и генетическая детерминация рака мочевого пузыря. В кн.: Клиническая онкоурология. Под ред. Б.П. Матвеева. М.: Вердана, 2003; с. 197−206.Матвеев Б.П. Статистика, эпидемиология и генетическая детерминация рака мочевого пузыря. В кн.: Клиническая онкоурология. Под ред. Б.П. Матвеева. М.: Вердана, 2003; с. 197−206.18. Dinney C.P.N., McConcey D.J., Millikan R.E. et al. Focus on bladder cancer. Cancer Cell 2004;6:111−6.Dinney C.P.N., McConcey D.J., Millikan R.E. et al. Focus on bladder cancer. Cancer Cell 2004;6:111−6.19. Zur Hauzen H. Infection causing human cancer. WILEY-VCH Verlag GmbH&Co., KgaA, Weiheim, Germany, 2006; p.182−3.Zur Hauzen H. Infection causing human cancer. WILEY-VCH Verlag GmbH&Co., KgaA, Weiheim, Germany, 2006; p.182−3.20. Adami J., Gabel H., Lindelof B. et al. Cancer risk following organ transplantation: a nationwide cohort study in Sweden. Br J Cancer 2003;89:1221−7.Adami J., Gabel H., Lindelof B. et al. Cancer risk following organ transplantation: a nationwide cohort study in Sweden. Br J Cancer 2003;89:1221−7.21. Bailar J.C. The incidence of independent tumors among uterine cancer patients. Cancer 1963;16:842−53.Bailar J.C. The incidence of independent tumors among uterine cancer patients. Cancer 1963;16:842−53.22. Newell G.R., Rawlings W., Krementz E.T., Roberts J.D. Multiple primary neoplasms in blacks compared to whites. III. Initial cancers at the female breast and uterus. J Natl Cancer Inst 1974;53:369−73.Newell G.R., Rawlings W., Krementz E.T., Roberts J.D. Multiple primary neoplasms in blacks compared to whites. III. Initial cancers at the female breast and uterus. J Natl Cancer Inst 1974;53:369−73.23. Newell G.R., Krementz E.T., Roberts J.D. Exess occurrence of cancer of the oral cavity, lung, and bladder following cancer of the cervix. Cancer 1975;36: 2155−8.Newell G.R., Krementz E.T., Roberts J.D. Exess occurrence of cancer of the oral cavity, lung, and bladder following cancer of the cervix. Cancer 1975;36: 2155−8.24. Durst M., Gissmann L., Ikenberg H., zur Hauzen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 1983;80:3812−5.Durst M., Gissmann L., Ikenberg H., zur Hauzen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 1983;80:3812−5.25. Querci della Rovere G., Oliver R.T., McCance D.J., Castro J.E. Development of bladder tumor containing HPV type 11 DNA after renal transplantation. Br J Urol 1988;62:36−8.Querci della Rovere G., Oliver R.T., McCance D.J., Castro J.E. Development of bladder tumor containing HPV type 11 DNA after renal transplantation. Br J Urol 1988;62:36−8.26. Del Mistro A., Koss L.G., Braunstein J. et al. Condyloma acuminata of the urinary bladder. Natural history, viral typing, and DNA content. Am J Surg Path 1988;12:205−12.Del Mistro A., Koss L.G., Braunstein J. et al. Condyloma acuminata of the urinary bladder. Natural history, viral typing, and DNA content. Am J Surg Path 1988;12:205−12.27. Kitamura T., Yogo Y., Ueki T. et al. Presence of human papillomavirus type 16 genome in bladder carcinoma in situ of a patient with mild immunodeficiency. Cancer Res 1988;48:7207−11.Kitamura T., Yogo Y., Ueki T. et al. Presence of human papillomavirus type 16 genome in bladder carcinoma in situ of a patient with mild immunodeficiency. Cancer Res 1988;48:7207−11.28. Maloney K.E., Wiener J.S., Walther P.J. Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: evaluation by differential polymerase chain reaction. J Urol 1994;151:360−4.Maloney K.E., Wiener J.S., Walther P.J. Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: evaluation by differential polymerase chain reaction. J Urol 1994;151:360−4.29. Barghi M.R., Hajimohammadmehdiarbab A., Moghaddam S.M., Kazemi B. Correlation between human papillomavirus infection and bladder transitional cell carcinoma. BMC Infect Dis 2005;5:102. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310619/Barghi M.R., Hajimohammadmehdiarbab A., Moghaddam S.M., Kazemi B. Correlation between human papillomavirus infection and bladder transitional cell carcinoma. BMC Infect Dis 2005;5:102. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310619/30. Moonen P.M., Bakkers J.M., Kiemeney L.A. et al. Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer. Eur Urol 2007;52(2):468−9.Moonen P.M., Bakkers J.M., Kiemeney L.A. et al. Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer. Eur Urol 2007;52(2):468−9.31. Yang H., Yang K., Khafagi A. et al. Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies. Proc Natl Acad Sci USA 2005;102(21):7683−8.Yang H., Yang K., Khafagi A. et al. Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies. Proc Natl Acad Sci USA 2005;102(21):7683−8.32. Helal Tel A., Fadel M.T., El-Sayed N.K. Human papilloma virus and p53 expression in bladder cancer in Egypt: correlation to schistosomiasis and clinicopathologic factors. Pathol Oncol Res 2006;12(3):173−8.Helal Tel A., Fadel M.T., El-Sayed N.K. Human papilloma virus and p53 expression in bladder cancer in Egypt: correlation to schistosomiasis and clinicopathologic factors. Pathol Oncol Res 2006;12(3):173−8.33. Badawi H., Ahmed H., Ismail A. et al. Role of human papillomavirus types 16, 18 and 52 in recurrent cystitis and urinary bladder cancer among Egyptian patients. Medscape J Med 2008;10:232. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605136/Badawi H., Ahmed H., Ismail A. et al. Role of human papillomavirus types 16, 18 and 52 in recurrent cystitis and urinary bladder cancer among Egyptian patients. Medscape J Med 2008;10:232. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605136/34. De Gaetani C., Ferrari G., Righi E. et al. Detection of human papillomavirus DNA in urinary bladder carcinoma by in situ hybridization. J Clin Pathol 1999;52:103−6.De Gaetani C., Ferrari G., Righi E. et al. Detection of human papillomavirus DNA in urinary bladder carcinoma by in situ hybridization. J Clin Pathol 1999;52:103−6.35. Франк Г.А., Завалишина Л.Э., Андреева Ю.Ю. Иммуногистохимическая характеристика и степень дифференцировки рака мочевого пузыря. Арх патол 2002;64(6):16−8.Франк Г.А., Завалишина Л.Э., Андреева Ю.Ю. Иммуногистохимическая характеристика и степень дифференцировки рака мочевого пузыря. Арх патол 2002;64(6):16−8.36. Volgareva G., Zavalishina L., Golovina D. et al. In search of bladder cancer markers: are human papillomaviruses and cellular INK4a expression associated? In: Tumor markers research perspectives. G.A. Sinise ed. NY: Nova Science Publishers, 2007; p.135−43.Volgareva G., Zavalishina L., Golovina D. et al. In search of bladder cancer markers: are human papillomaviruses and cellular INK4a expression associated? In: Tumor markers research perspectives. G.A. Sinise ed. NY: Nova Science Publishers, 2007; p.135−43.37. Volgareva G.M., Kuevda D.A., Zavalishina L.E. et al. Human papillomaviruses: is bladder urothelium a target of their carcinogenic action? World Cancer Congress UICC Geneva 2008. Int J Cancer 2008; (Suppl):216.Volgareva G.M., Kuevda D.A., Zavalishina L.E. et al. Human papillomaviruses: is bladder urothelium a target of their carcinogenic action? World Cancer Congress UICC Geneva 2008. Int J Cancer 2008; (Suppl):216.38. Volgareva G., Trofimova O., Kuevda D. et al. HPV and urinary bladder cancer. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009. Abstract book; p.18−42.Volgareva G., Trofimova O., Kuevda D. et al. HPV and urinary bladder cancer. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009. Abstract book; p.18−42.39. Trofimova O., Kuevda D., Shipulina O., Volgareva G. Development of HPV genotyping and expression methods and validation on group of urinary bladder cancer. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009. Abstract book; p.29−58.Trofimova O., Kuevda D., Shipulina O., Volgareva G. Development of HPV genotyping and expression methods and validation on group of urinary bladder cancer. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009. Abstract book; p.29−58.40. Волгарева Г.М., Завалишина Л.Э., Головина Д.А. и др. Обнаружение онкобелка E7 HPV16 в раковом и нормальном уротелии мочевого пузыря. Арх патол 2009;71(1):29−30.Волгарева Г.М., Завалишина Л.Э., Головина Д.А. и др. Обнаружение онкобелка E7 HPV16 в раковом и нормальном уротелии мочевого пузыря. Арх патол 2009;71(1):29−30.41. Cheng S., Hsiao L., Jung S., Volgareva G.M. Detection of HPV E6 and E7 oncoproteins in bladder cancers. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009. Abstract book; p.14−9.Cheng S., Hsiao L., Jung S., Volgareva G.M. Detection of HPV E6 and E7 oncoproteins in bladder cancers. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009. Abstract book; p.14−9.42. Волгарева Г.М., Завалишина Л.Э., Трофимова О.Б. и др. Причастны ли вирусы папиллом человека к возникновению рака мочевого пузыря? Описание клинического случая. Арх патол 2010;72(3).Волгарева Г.М., Завалишина Л.Э., Трофимова О.Б. и др. Причастны ли вирусы папиллом человека к возникновению рака мочевого пузыря? Описание клинического случая. Арх патол 2010;72(3).43. Волгарева Г.М., Завалишина Л.Э., Головина Д.А. и др. Экспрессия гена INK4a в клетках рака мочевого пузыря, ассоциированного с вирусом папиллом человека 16-го типа. Бюлл экспер биол мед 2010;149(2):204−8.Волгарева Г.М., Завалишина Л.Э., Головина Д.А. и др. Экспрессия гена INK4a в клетках рака мочевого пузыря, ассоциированного с вирусом папиллом человека 16-го типа. Бюлл экспер биол мед 2010;149(2):204−8.44. Ruas M., Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1998;1378:115−77.Ruas M., Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1998;1378:115−77.45. Aveyard J.S., Knowles M.A. Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligationdependent probe amplification J Mol Diagnost 2004;6(4):356−64.Aveyard J.S., Knowles M.A. Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligationdependent probe amplification J Mol Diagnost 2004;6(4):356−64.46. Gallucci M., Vico E., Merola R. et al. Adverse genetic prognostic profiles define a poor outcome for cystectomy in bladder cancer. Exp Mol Pathol 2007;83:385−91.Gallucci M., Vico E., Merola R. et al. Adverse genetic prognostic profiles define a poor outcome for cystectomy in bladder cancer. Exp Mol Pathol 2007;83:385−91.47. Энциклопедический словарь медицинских терминов. М.: Советская энциклопедия, 1984.Энциклопедический словарь медицинских терминов. М.: Советская энциклопедия, 1984.48. Campo M.S., Jarrett W.F., Barron R. et al. Association of bovine papillomavirus type 2 and braken fern with bladder cancer in cattle. Cancer Res 1992;52:6898−904.Campo M.S., Jarrett W.F., Barron R. et al. Association of bovine papillomavirus type 2 and braken fern with bladder cancer in cattle. Cancer Res 1992;52:6898−904.49. Campo M.S. Animal models of papillomavirus pathogenesis. Virus Res 2002;89:249−61.Campo M.S. Animal models of papillomavirus pathogenesis. Virus Res 2002;89:249−61.50. Campo M.S., Beniston R.G., Connolly J.A., Grindlay G.J. Synergism between papillomavirus and braken fern in carcinogenesis of the upper gastrointestinal tract in cattle and humans: quercetin and cell transformation. In: Braken fern: toxicity, biology and control. Taylor J.A., Smith R.T. eds.Manchester, 1999; p. 116−22.Campo M.S., Beniston R.G., Connolly J.A., Grindlay G.J. Synergism between papillomavirus and braken fern in carcinogenesis of the upper gastrointestinal tract in cattle and humans: quercetin and cell transformation. In: Braken fern: toxicity, biology and control. Taylor J.A., Smith R.T. eds.Manchester, 1999; p. 116−22.51. Reznikoff C.A., Belair C., Savelieva E. et al. Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells. Gen Dev 1994;8:2227−40.Reznikoff C.A., Belair C., Savelieva E. et al. Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells. Gen Dev 1994;8:2227−40.52. Андреева Ю.Ю., Завалишина Л.Э., Морозов А.А. и др. Выявление ДНК вируса папилломы человека в поверхностной уротелиальной карциноме мочевого пузыря. Онкоурология 2008;(1):34−5.Андреева Ю.Ю., Завалишина Л.Э., Морозов А.А. и др. Выявление ДНК вируса папилломы человека в поверхностной уротелиальной карциноме мочевого пузыря. Онкоурология 2008;(1):34−5.53. Lopes-Beltran A., Escudero A.L.,Vicioso L. et al. Human papillomavirus DNA as a factor determining the survival of bladder cancer patients. Br J Cancer 1996;73:124−7.Lopes-Beltran A., Escudero A.L.,Vicioso L. et al. Human papillomavirus DNA as a factor determining the survival of bladder cancer patients. Br J Cancer 1996;73:124−7.54. Hellner K., Baldwin A., Xian J. et al. PAK3 inhibitors identified by high-throughputscreening as therapeutics for HPV-associated cancers. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009.Abstract book: oral presentation O-09.05.Hellner K., Baldwin A., Xian J. et al. PAK3 inhibitors identified by high-throughputscreening as therapeutics for HPV-associated cancers. 25-th International Papillomavirus Conference, Malmo, Sweden, May 2009.Abstract book: oral presentation O-09.05.