Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press36710.17650/1726-9776-2010-6-4-71-77PROSTATE CANCERРАК ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫLEUPRORELIN ACETATE DEPOT (ELIGARD) IN THE TREATMENT OF PROSTATE CANCER: WHAT DO PATIENTS WIN?ДЕПО-ФОРМА ЛЕЙПРОРЕЛИНА АЦЕТАТА (ЭЛИГАРД) В ЛЕЧЕНИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ: ЧТО ВЫИГРЫВАЮТ ПАЦИЕНТЫ?MatveevV. B.МатвеевВ. Б.
Russian Federation
mivolkova@rambler.ruVolkovaM. I.ВолковаМ. И.
Russian Federation
mivolkova@rambler.ruKupchanD. Z.КупчанД. З.
Russian Federation
mivolkova@rambler.ruGridnevaYa. V.ГридневаЯ. В.
Russian Federation
mivolkova@rambler.ruN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowГУ РОНЦ им. Н.Н. Блохина РАМН, Москва301220106471771509201415092014https://oncourology.abvpress.ru/oncur/article/view/367

Eligard (leupropelin acetate, Atrigel delivery system) is a synthetic analogue of luteinizing-hormone-realizing hormone (LHRH), which causes a rapid reduction in the level of testosterone to the concentration comparable with that after surgical castration. Eligard demonstrated a considerable advantage over other LHRH analogues in the depth of androgenic suppression and in the frequency of transient increases in testosterone levels at the beginning and during therapy. Eligard is available as 1-, 3-, and 6-month depot formulations, which allows a flexible approach to be applied to individually making up a therapy regimen. Eligard is as effective as castration therapy techniques. Treatment with this drug shows the low frequency of side effects and is well tolerated by patients.

Элигард (лейпрорелина ацетат, система доставки Атригель) - синтетический аналог лютеинизирующего гормона рилизинг- гормона (ЛГРГ), вызывающий быстрое снижение уровня тестостерона до концентрации, сравнимой с таковой после хирургической кастрации. Элигард продемонстрировал значительное преимущество в отношении глубины андрогенной супрессии, а также частоты транзиторных повышений уровня тестостерона в начале и на фоне лечения перед другими аналогами ЛГРГ. Элигард доступен в виде 1-, 3- и 6-месячной депо-форм, что предоставляет возможность гибкого подхода к индивидуальному формированию режима терапии. Эффективность Элигарда не уступает методам кастрационной терапии. Лечение Элигардом ассоциировано с низкой частотой побочных эффектов и хорошо переносится больными.

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