Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press34910.17650/1726-9776-2012-8-4-10-14DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. RENAL CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак почкиROLE OF THE MORPHOMETRIC PARAMETERS OF INTRATUMORAL MICROVESSELS AND THE PROLIFERATIVE ACTIVITY OF TUMOR CELLS IN RENAL CELL CARCINOMAРОЛЬ МОРФОМЕТРИЧЕСКИХ ПОКАЗАТЕЛЕЙ ВНУТРИОПУХОЛЕВЫХ МИКРОСОСУДОВ И ПРОЛИФЕРАТИВНОЙ АКТИВНОСТИ ОПУХОЛЕВЫХ КЛЕТОК ПРИ ПОЧЕЧНО-КЛЕТОЧНОМ РАКЕGorbanN. A.ГорбаньН. А.
Russian Federation
perovanina@mail.ruKaryakinO. B.КарякинО. Б.
Russian Federation
perovanina@mail.ruPopovA. M.ПоповА. М.
Russian Federation
perovanina@mail.ruIvanovaS. V.ИвановаС. В.
Russian Federation
perovanina@mail.ruKudaibergenovaA. G.КудайбергеноваА. Г.
Russian Federation
perovanina@mail.ruKondrashovaL. M.КондрашоваЛ. М.
Russian Federation
perovanina@mail.ruBarkhatovA. E.БархатовА. Э.
Russian Federation
perovanina@mail.ruMedical Radiology Research Center, ObninskМРНЦ, ОбнинскRussian Research Center of Radiology and Surgical Technologies, Saint PetersburgРНЦРХТ, Санкт-Петербург301220128410140608201406082014https://oncourology.abvpress.ru/oncur/article/view/349

Tumor cell proliferation and angiogenesis are essential factors for tumor growth, progression, and metastasis.

Objective: to assess the relationship between the values of proliferative activity and the morphometric parameters of intratumoral microvessels in metastatic and localized carcinomas of the kidney.

Materials and methods. Surgical specimens taken from 54 patients (32 men and 22 women) aged 26 to 69 years (mean age 55 ± 1.5 years) with the verified diagnosis of clear-cell renal cell carcinoma (RCC) were studied.

Conclusion. Proliferative activity and angioarchitectonics are an important biological characteristic of a tumor of unequal clinical value in RCC. Metastatic carcinoma has a higher proliferative activity and a low tumor vascularization than those of localized carcinoma.

Необходимыми факторами для опухолевого роста, прогрессии и метастазирования являются пролиферация опухолевых клеток и опухолевый ангиогенез.

Цель исследования – оценка взаимоотношения показателей пролиферативной активности и морфометрических параметров внутриопухолевых микрососудов в метастатических и локализованных карциномах почки.

Материалы и методы. Исследован операционный материал, взятый от 54 пациентов (32 мужчины и 22 женщины) в возрасте от 26 до 69 лет (средний возраст 55 ± 1,5 года) с верифицированным диагнозом: почечно-клеточный рак (ПКР), светлоклеточный вариант.

Выводы. Пролиферативная активность и ангиоархитектоника являются важной биологической характеристикой опухоли с неодинаковой клинической значимостью при ПКР. Метастатический рак имеет более высокую пролиферативную активность и низкий уровень васкуляризации опухоли по сравнению с локализованным раком.

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