Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press3410.17650/1726-9776-2014-10-2-12-15LECTUREЛЕКЦИЯDIAGNOSIS OF NON-MUSCLE-INVASIVE PAPILLARY BLADDER TUMORS: CLASSIFICATIONAL AND MORPHOLOGICAL ASPECTSКЛАССИФИКАЦИОННЫЕ И МОРФОЛОГИЧЕСКИЕ АСПЕКТЫ ДИАГНОСТИКИ НЕМЫШЕЧНО-ИНВАЗИВНЫХ ПАПИЛЛЯРНЫХ ОПУХОЛЕЙ МОЧЕВОГО ПУЗЫРЯGorbanN. A.ГорбаньН. А.
Russian Federation
perovanina@mail.ruPugachevV. V.ПугачевВ. В.
Russian Federation
perovanina@mail.ruKaryakinO. B.КарякинО. Б.
Russian Federation
perovanina@mail.ruMedical Radiology Research Center, ObninskМедицинский радиологический научный центр, Обнинск3006201410212152407201424072014https://oncourology.abvpress.ru/oncur/article/view/34

The diagnosis of superficial papillary bladder tumors remains a serious problem and has 2 aspects: classificational and morphological ones. As of now, 2 classifications of superficial bladder tumors, the basis for which is different principles (the 1973 WHO and the 2004 WHO ones) are equally used. Pathologists and clinicians must know criteria for both classifications and understand their differences, advantages, and disadvantages. If they are unaware of the normal structure of the bladder and the specific features of work with transurethral resection material, they cannot adequately stage non-muscle-invasive tumors.

Диагностика поверхностных папиллярных опухолей мочевого пузыря (МП) остается серьезной проблемой и имеет 2 аспекта: классификационный и морфологический. В настоящее время равноправно используются 2 классификации поверхностных опухолей МП, в основу которых положены разные принципы, – ВОЗ 1973 г. и ВОЗ 2004 г. Патологоанатомы и клиницисты должны знать критерии обеих классификаций и понимать их различия, преимущества и недостатки. Адекватное стадирование немышечно-инвазивных опухолей невозможно без знания нормального строения МП и особенностей работы с материалом трансуретральной резекции.

 

classification of superficial bladder tumorsthe 1973 WHO classificationthe 2004 WHO classificationpapillary urothelial cancerurothelial papillomacarcinoma in situклассификация поверхностных опухолей мочевого пузыряклассификация ВОЗ 1973 г.классификация ВОЗ 2004 г.папиллярный уротелиальный ракуротелиальная папилломакарцинома in situ1. Мостофи Ф.К., Собин Л.Г., Торлони Г. и др. Гистологическая классификация опухолей мочевого пузыря. Женева: ВОЗ, 1977. 35 с.Мостофи Ф.К., Собин Л.Г., Торлони Г. и др. Гистологическая классификация опухолей мочевого пузыря. Женева: ВОЗ, 1977. 35 с.2. World Health Organization Classification of Tumours. Pathology & Genetics: Tumours of the Urinary System and Male Genital Organs. Lyon, France: IARC Press, 2004.World Health Organization Classification of Tumours. Pathology & Genetics: Tumours of the Urinary System and Male Genital Organs. Lyon, France: IARC Press, 2004.3. Mostofi F.K. Pathological aspects and spread of carcinoma of the bladder. JAMA 1968;206(8):1764–9.Mostofi F.K. Pathological aspects and spread of carcinoma of the bladder. JAMA 1968;206(8):1764–9.4. Miyamoto H., Miller J.S., Fajardo D.A. et al. Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system. Pathol Int 2010;60(1):1–8. Erratum in: Pathol Int 2010;60(2):147.Miyamoto H., Miller J.S., Fajardo D.A. et al. Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system. Pathol Int 2010;60(1):1–8. Erratum in: Pathol Int 2010;60(2):147.5. Simon R., Bьrger H., Brinkschmidt C. et al. Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol 1998;185(4):345–51.Simon R., Bьrger H., Brinkschmidt C. et al. Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol 1998;185(4):345–51.6. Lopez-Beltran A., Cheng L., Mazzucchelli R. et al. Morphological and molecular profiles and pathways in bladder neoplasms. Anticancer Res 2008;28(5B):2893–900.Lopez-Beltran A., Cheng L., Mazzucchelli R. et al. Morphological and molecular profiles and pathways in bladder neoplasms. Anticancer Res 2008;28(5B):2893–900.7. Hofmann T., Knuchel-Clarke R., Hartmann A. et al. Clinucal Implications of the 2004 WHO Histological Classification on Non-Invasive Tumours of the Urinary Bladder. EAU-EBU Update Series 4 (2004):83–95.Hofmann T., Knuchel-Clarke R., Hartmann A. et al. Clinucal Implications of the 2004 WHO Histological Classification on Non-Invasive Tumours of the Urinary Bladder. EAU-EBU Update Series 4 (2004):83–95.8. Montironi R., Lopez-Beltran A., Scarpelli M. et al. Morphological classification and definition of benign, preneoplastic and non-invasive neoplastic lesions of the urinary bladder. Histopathology 2008;53(6):621–33.Montironi R., Lopez-Beltran A., Scarpelli M. et al. Morphological classification and definition of benign, preneoplastic and non-invasive neoplastic lesions of the urinary bladder. Histopathology 2008;53(6):621–33.9. Montironi R., Mazzucchelli R., Scarpelli M. et al. Morphological diagnosis of urothelial neoplasms. J Clin Pathol 2008;61(1):3–10.Montironi R., Mazzucchelli R., Scarpelli M. et al. Morphological diagnosis of urothelial neoplasms. J Clin Pathol 2008;61(1):3–10.10. MacLennan G.T., Kirkali Z., Cheng L. Histologic grading of noninvasive papillary uro-thelial neoplasms. Eur Urol 2007;51(4):889–97.MacLennan G.T., Kirkali Z., Cheng L. Histologic grading of noninvasive papillary uro-thelial neoplasms. Eur Urol 2007;51(4):889–97.11. May M., Brookman-Amissah S., Roigas J. et al. Prognostic accuracy of individual uropathologists in noninvasive urinary bladder carcinoma: a multicentre study comparing the 1973 and 2004 World Health Organisation classifications. Eur Urol 2010;57(5):850–8.May M., Brookman-Amissah S., Roigas J. et al. Prognostic accuracy of individual uropathologists in noninvasive urinary bladder carcinoma: a multicentre study comparing the 1973 and 2004 World Health Organisation classifications. Eur Urol 2010;57(5):850–8.12. Lopez-Beltran A., Montironi R. Non-invasive urothelial neoplasms: according to the most recent WHO classification. Eur Urol 2004;46(2):170–6.Lopez-Beltran A., Montironi R. Non-invasive urothelial neoplasms: according to the most recent WHO classification. Eur Urol 2004;46(2):170–6.13. Montironi R., Cheng L., Scarpelli M. et al. How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme? Diagn Pathol 2011;6:31.Montironi R., Cheng L., Scarpelli M. et al. How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme? Diagn Pathol 2011;6:31.14. Cheng L., Montironi R., Davidson D.D., Lopez-Beltran A. Staging and reporting of urothelial carcinoma of the urinary bladder. Mod Pathol 2009;22(Suppl 2):70–95.Cheng L., Montironi R., Davidson D.D., Lopez-Beltran A. Staging and reporting of urothelial carcinoma of the urinary bladder. Mod Pathol 2009;22(Suppl 2):70–95.15. Pan C.C., Chang Y.H., Chen K.K. et al. Prognostic significance of the 2004 WHO/ISUP classification for prediction of recurrence, progression, and cancer-specific mortality of non-muscle-invasive urothelial tumors of the urinary bladder: a clinicopathologic study of 1,515 cases. Am J Clin Pathol 2010;133(5):788–95.Pan C.C., Chang Y.H., Chen K.K. et al. Prognostic significance of the 2004 WHO/ISUP classification for prediction of recurrence, progression, and cancer-specific mortality of non-muscle-invasive urothelial tumors of the urinary bladder: a clinicopathologic study of 1,515 cases. Am J Clin Pathol 2010;133(5):788–95.16. Petersen R.O., Sesterhenn I.A., Davis C.J. Urologic Pathology. Lippincott Williams & Wilkins, 2009. 636 p.Petersen R.O., Sesterhenn I.A., Davis C.J. Urologic Pathology. Lippincott Williams & Wilkins, 2009. 636 p.