Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press31410.17650/1726-9776-2012-8-2-32-36DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCERДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫ. Рак мочевого пузыряMOLECULAR PROGNOSTIC MARKERS OF URINE BLADDER CANCERМОЛЕКУЛЯРНЫЕ МАРКЕРЫ ПРОГНОЗА ПРИ РАКЕ МОЧЕВОГО ПУЗЫРЯPavlovV. N.ПавловВ. Н.
Russian Federation
Izmailov75@mail.ruIzmailovA. A.ИзмайловА. А.
Russian Federation
Izmailov75@mail.ruAkhmadishinaL. Z.АхмадишинаЛ. З.
Russian Federation
Izmailov75@mail.ruVictorovaT. V.ВиктороваТ. В.
Russian Federation
Izmailov75@mail.ruIzmailovaS. M.ИзмайловаС. М.
Russian Federation
Izmailov75@mail.ruUrmantsevM. F.УрманцевМ. Ф.
Russian Federation
Izmailov75@mail.ruAlekseevA. V.АлексеевА. В.
Russian Federation
Izmailov75@mail.ruZagitovA. R.ЗагитовА. Р.
Russian Federation
Izmailov75@mail.ruKutliyarovL. M.КутлияровЛ. М.
Russian Federation
Izmailov75@mail.ruClinic of Bashkir State Medical University, Ufa Bashkir State Medical University, UfaКлиника Башкирского ГМУ, Уфа ГБОУ ВПО Башкирский ГМУ Минздравсоцразвития России, УфаClinic of Bashkir State Medical University, UfaКлиника Башкирского ГМУ, УфаInstitute of Biochemistry and Genetics, UfaФГБУН Институт биохимии и генетики Уфимского НЦ РАНBashkir State Medical University, Ufa Institute of Biochemistry and Genetics, UfaГБОУ ВПО Башкирский ГМУ Минздравсоцразвития России, Уфа ФГБУН Институт биохимии и генетики Уфимского НЦ РАНBashkir State Medical University, UfaГБОУ ВПО Башкирский ГМУ Минздравсоцразвития России, Уфа300620128232360508201405082014https://oncourology.abvpress.ru/oncur/article/view/314

Bladder cancer (BC) remains a current problem in oncourology. Despite that bladder cancer risk factors have been studied and described in the literature, new molecular and genetic mechanisms have been identified that predisposes to the disease development. There are numerous cellular processes involve in BC pathogenesis. The less-aggressive, non-invasive slow progressing bladder cancer types are defined by Ras-MAPK system activation. Tumors that are more aggressive and have low cancer-specific survival rate are characterized by changes in retinoblastoma genes and p53. Attempts are made to develop prognostic tests to predict tumor behavior, targeted treatment. perspectively, BC patients will be treated using molecular genetic markers allowing the accurate prediction of the patient’s tumor behavior and fitting the treatment tactics on the individual basis.

Рак мочевого пузыря (РМП) остается актуальной проблемой онкоурологии. Несмотря на то, что факторы риска РМП изучены и описаны в литературе, выявляются новые молекулярно-генетические механизмы, предрасполагающие к развитию заболевания. В патогенез РМП вовлечено множество клеточных процессов. Менее агрессивные, неинвазивные, медленно прогрессирующие формы РМП характеризуются активацией системы Ras-mitogen-activated protein kinase (Ras-MAPK). Более агрессивные опухоли с низкой раковоспецифической выживаемостью, характеризуются изменениями в генах ретинобластомы и p53. Предпринимаются попытки разработать прогностические тесты, предсказывающие развитие опухоли, выбор тактики лечения. В перспективе в лечении пациентов РМП будут использоваться молекулярно-генетические маркеры, позволяющие достоверно предсказать поведение опухоли у пациента и выбрать индивидуальную тактику лечения.

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