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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2010-6-1-69-75</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">CURRENT VIEWS OF THE GLEASON GRADING SYSTEM</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О СИСТЕМЕ ГРАДАЦИИ ГЛИСОНА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gorban</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Горбань</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kudaibergenova</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Кудайбергенова</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk</institution></aff><aff><institution xml:lang="ru">МРНЦ РАМН, Обнинск</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Research Center, Federal Agency for High-Technology Medical Care, Saint Petersburg</institution></aff><aff><institution xml:lang="ru">ФГУ Российский научный центр радиологии и хирургических технологий Федерального агентства по высокотехнологичной медицинской помощи, Санкт-Петербург</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-03-30" publication-format="electronic"><day>30</day><month>03</month><year>2010</year></pub-date><volume>6</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>69</fpage><lpage>75</lpage><history><date date-type="received" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/31">https://oncourology.abvpress.ru/oncur/article/view/31</self-uri><abstract xml:lang="en"><p>The authors provide the proceedings of the 2005 First International Society of Urological Pathology Consensus Conference and the basic provisions that differ the modified Gleason grading system from its original interpretation. In particular, we should do away with Gleason grade 1 (or 1 + 1 = 2) while assessing the needle biopsy specimens. Contrary to the recommendations by Gleason himself, the conference decided to apply stringent criteria for using Gleason grades 3 and 4. This is due to the fact that these grades are of special prognostic value so it is important to have clear criteria in defining each Gleason grade. Notions, such as secondary and tertiary Gleason patterns, are considered; detailed recommendations are given on the lesion extent sufficient to diagnose these components.</p></abstract><trans-abstract xml:lang="ru"><p>The authors provide the proceedings of the 2005 First International Society of Urological Pathology Consensus Conference and the basic provisions that differ the modified Gleason grading system from its original interpretation. In particular, we should do away with Gleason grade 1 (or 1 + 1 = 2) while assessing the needle biopsy specimens. Contrary to the recommendations by Gleason himself, the conference decided to apply stringent criteria for using Gleason grades 3 and 4. This is due to the fact that these grades are of special prognostic value so it is important to have clear criteria in defining each Gleason grade. Notions, such as secondary and tertiary Gleason patterns, are considered; detailed recommendations are given on the lesion extent sufficient to diagnose these components.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Gleason scale gradation</kwd><kwd>criteria</kwd><kwd>differentiation</kwd><kwd>malignant component</kwd><kwd>malignancy grade</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Bailar J.C. 3rd, Mellinger G.T., Gleason D.F. Survival rates of patients with prostatic cancer, tumor stage, and differentiation: preliminary report. Cancer Chemother Rep 1966;50:129-36.</mixed-citation><mixed-citation xml:lang="ru">Bailar J.C. 3rd, Mellinger G.T., Gleason D.F. Survival rates of patients with prostatic cancer, tumor stage, and differentiation: preliminary report. Cancer Chemother Rep 1966;50:129-36.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Gleason D.F. Classification of prostatic carcinomas. Cancer Chemother Rep 1966;50:125-8.</mixed-citation><mixed-citation xml:lang="ru">Gleason D.F. Classification of prostatic carcinomas. Cancer Chemother Rep 1966;50:125-8.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Mellinger G.T., Gleason D., Bailar J. 3rd. The histology and prognosis of prostatic cancer. J Urol 1967;97:331-7.</mixed-citation><mixed-citation xml:lang="ru">Mellinger G.T., Gleason D., Bailar J. 3rd. The histology and prognosis of prostatic cancer. J Urol 1967;97:331-7.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Gleason D.F., Mellinger G.T. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 1974;11:58-64.</mixed-citation><mixed-citation xml:lang="ru">Gleason D.F., Mellinger G.T. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 1974;11:58-64.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Epstein J.I., Algaba F., Allsbrook J. et al. Acinar adenocarcinoma. In: J.N. Eble, G. Sauter, J.I. Epstein et al., eds. World Health Organization Classification of Tumours. Pathology &amp; Genetics: Tumours of the urinary system and male genital organs. Lyon, France: IARC Press, 2004. p. 179-84.</mixed-citation><mixed-citation xml:lang="ru">Epstein J.I., Algaba F., Allsbrook J. et al. Acinar adenocarcinoma. In: J.N. Eble, G. Sauter, J.I. Epstein et al., eds. World Health Organization Classification of Tumours. Pathology &amp; Genetics: Tumours of the urinary system and male genital organs. Lyon, France: IARC Press, 2004. p. 179-84.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Amin M.B., Schultz D.S., Zarbo R.J. Analysis of cribriform morphology in prostatic neoplasia using antibody to high molecular-weight cytokeratin. Arch Pathol Lab Med 1994;118:260-4.</mixed-citation><mixed-citation xml:lang="ru">Amin M.B., Schultz D.S., Zarbo R.J. Analysis of cribriform morphology in prostatic neoplasia using antibody to high molecular-weight cytokeratin. Arch Pathol Lab Med 1994;118:260-4.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Epstein J.I., Allsbrook J., Amin M.B. et al. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostate Carcinoma. Am J Surg Pathol 2005;29:1228-42.</mixed-citation><mixed-citation xml:lang="ru">Epstein J.I., Allsbrook J., Amin M.B. et al. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostate Carcinoma. Am J Surg Pathol 2005;29:1228-42.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Gleason D.F. Histological grading and clinical staging of prostatic carcinoma. In: M. Tannenbaum, ed. Urologic Pathology: The Prostate. Philadelphia: Lea &amp; Feibiger, 1977. p. 171-98.</mixed-citation><mixed-citation xml:lang="ru">Gleason D.F. Histological grading and clinical staging of prostatic carcinoma. In: M. Tannenbaum, ed. Urologic Pathology: The Prostate. Philadelphia: Lea &amp; Feibiger, 1977. p. 171-98.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Epstein J.I. Gleason score 2-4 adenocarcinoma of the prostate on needle biopsy: a diagnosis that should not be made. Am J Surg Pathol 2000;24:477-8.</mixed-citation><mixed-citation xml:lang="ru">Epstein J.I. Gleason score 2-4 adenocarcinoma of the prostate on needle biopsy: a diagnosis that should not be made. Am J Surg Pathol 2000;24:477-8.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Steinberg D.M., Sauvageot J., Piantadosi S. et al. Correlation of prostate needle biopsy and radical prostatectomy Gleason grade in academic and community settings. Am J Surg Pathol 1997;21: 566-76.</mixed-citation><mixed-citation xml:lang="ru">Steinberg D.M., Sauvageot J., Piantadosi S. et al. Correlation of prostate needle biopsy and radical prostatectomy Gleason grade in academic and community settings. Am J Surg Pathol 1997;21: 566-76.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Nelson R.S., Epstein J.I. Prostatic carcinoma with abundant xanthomatous cytoplasm: foamy gland carcinoma. Am J Surg Pathol 1996;20:419-26.</mixed-citation><mixed-citation xml:lang="ru">Nelson R.S., Epstein J.I. Prostatic carcinoma with abundant xanthomatous cytoplasm: foamy gland carcinoma. Am J Surg Pathol 1996;20:419-26.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Tran T.T., Sengupta E., Yang X.J. Prostatic foamy gland carcinoma with aggressive behavior: clinicopathologic, immunohistochemical, and ultrastructural analysis. Am J Surg Pathol 2001; 25:618-23.</mixed-citation><mixed-citation xml:lang="ru">Tran T.T., Sengupta E., Yang X.J. Prostatic foamy gland carcinoma with aggressive behavior: clinicopathologic, immunohistochemical, and ultrastructural analysis. Am J Surg Pathol 2001; 25:618-23.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Epstein J.I., Lieberman P.H. Mucinous adenocarcinoma of the prostate gland. Am J Surg Pathol 1985;9:299-308.</mixed-citation><mixed-citation xml:lang="ru">Epstein J.I., Lieberman P.H. Mucinous adenocarcinoma of the prostate gland. Am J Surg Pathol 1985;9:299-308.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Ro J.Y., Grignon D.J., Ayala A.G. et al. Mucinous adenocarcinoma of the prostate: histochemical and immunohistochemical studies. Hum Pathol 1990;21:593-600.</mixed-citation><mixed-citation xml:lang="ru">Ro J.Y., Grignon D.J., Ayala A.G. et al. Mucinous adenocarcinoma of the prostate: histochemical and immunohistochemical studies. Hum Pathol 1990;21:593-600.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Baisden B.L., Kahane H., Epstein J.I. Perineural invasion, mucinous fibroplasia, and glomerulations: diagnostic features of limited cancer on prostate needle biopsy. Am J Surg Pathol 1999;23:918-24.</mixed-citation><mixed-citation xml:lang="ru">Baisden B.L., Kahane H., Epstein J.I. Perineural invasion, mucinous fibroplasia, and glomerulations: diagnostic features of limited cancer on prostate needle biopsy. Am J Surg Pathol 1999;23:918-24.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Pacelli A., Lopez-Beltran A., Egan A.J. et al. Prostatic adenocarcinoma with glomeruloid features. Hum Pathol 1998;29:543-6.</mixed-citation><mixed-citation xml:lang="ru">Pacelli A., Lopez-Beltran A., Egan A.J. et al. Prostatic adenocarcinoma with glomeruloid features. Hum Pathol 1998;29:543-6.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Humphrey P.A., Kaleem Z., Swanson P.E. et al. Pseudohyperplastic prostatic adenocarcinoma. Am J Surg Pathol 1998;22:1239-46.</mixed-citation><mixed-citation xml:lang="ru">Humphrey P.A., Kaleem Z., Swanson P.E. et al. Pseudohyperplastic prostatic adenocarcinoma. Am J Surg Pathol 1998;22:1239-46.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Levi A.W., Epstein J.I. Pseudohyperplastic prostatic adenocarcinoma on needle biopsy and simple prostatectomy. Am J Surg Pathol 2000;24: 1039-46.</mixed-citation><mixed-citation xml:lang="ru">Levi A.W., Epstein J.I. Pseudohyperplastic prostatic adenocarcinoma on needle biopsy and simple prostatectomy. Am J Surg Pathol 2000;24: 1039-46.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Brinker D.A., Potter S.R., Epstein J.I. Ductal adenocarcinoma of the prostate diagnosed on needle biopsy: correlation with clinical and radical prostatectomy findings and progression. Am J Surg Pathol 1999;23: 1471-9.</mixed-citation><mixed-citation xml:lang="ru">Brinker D.A., Potter S.R., Epstein J.I. Ductal adenocarcinoma of the prostate diagnosed on needle biopsy: correlation with clinical and radical prostatectomy findings and progression. Am J Surg Pathol 1999;23: 1471-9.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. DiBlasio C.J., Rhee A.C., Cho D. et al. Predicting clinical end points: treatment nomograms in prostate cancer. Semin Oncol 2003;30:567-86.</mixed-citation><mixed-citation xml:lang="ru">DiBlasio C.J., Rhee A.C., Cho D. et al. Predicting clinical end points: treatment nomograms in prostate cancer. Semin Oncol 2003;30:567-86.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Partin A.W., Kattan M.W.,Subong E.N. et al. Combination of prostatespecific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer: a multi-institutional update. JAMA 1997;277: 1445-51.</mixed-citation><mixed-citation xml:lang="ru">Partin A.W., Kattan M.W.,Subong E.N. et al. Combination of prostatespecific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer: a multi-institutional update. JAMA 1997;277: 1445-51.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Mosse C.A., Magi-Galluzzi C.,Tsuzuki T. et al. The prognostic significance of tertiary Gleason pattern 5 in radical prostatectomy specimens. Am J Surg Pathol 2004;28:394-8.</mixed-citation><mixed-citation xml:lang="ru">Mosse C.A., Magi-Galluzzi C.,Tsuzuki T. et al. The prognostic significance of tertiary Gleason pattern 5 in radical prostatectomy specimens. Am J Surg Pathol 2004;28:394-8.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Stamey T.A., McNeal J.E.,Yemoto C.M. et al. Biological determinants of cancer progression in men with prostate cancer. JAMA 1999;281:1395-400.</mixed-citation><mixed-citation xml:lang="ru">Stamey T.A., McNeal J.E.,Yemoto C.M. et al. Biological determinants of cancer progression in men with prostate cancer. JAMA 1999;281:1395-400.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Cohen M.B., Soloway M.S.,Murphy W.M. Sampling of radical prostatectomy specimens: how much is adequate? Am J Clin Pathol 1994;101:250-2.</mixed-citation><mixed-citation xml:lang="ru">Cohen M.B., Soloway M.S.,Murphy W.M. Sampling of radical prostatectomy specimens: how much is adequate? Am J Clin Pathol 1994;101:250-2.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Sehdev A.E., Pan C.C., Epstein J.I. Comparative analysis of sampling methods for grossing radical prostatectomy specimens performed for nonpalpable (stage T1c) prostatic adenocarcinoma. Hum Pathol 2001;32:494-9.</mixed-citation><mixed-citation xml:lang="ru">Sehdev A.E., Pan C.C., Epstein J.I. Comparative analysis of sampling methods for grossing radical prostatectomy specimens performed for nonpalpable (stage T1c) prostatic adenocarcinoma. Hum Pathol 2001;32:494-9.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Rubin M.A., Bismar T.A., Curtis S. et al. Prostate needle biopsy reporting: how are the surgical members of the Society of Urologic Oncology using pathology reports to guide treatment of prostate cancer patients? Am J Surg Pathol 2004;28: 946-52.</mixed-citation><mixed-citation xml:lang="ru">Rubin M.A., Bismar T.A., Curtis S. et al. Prostate needle biopsy reporting: how are the surgical members of the Society of Urologic Oncology using pathology reports to guide treatment of prostate cancer patients? Am J Surg Pathol 2004;28: 946-52.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
