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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">309</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2012-8-3-12-17</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">MAINTENANCE INTRAVESICULAR THERAPY WITH BCG VACCINE AS A STANDARD FOR THE PREVENTION AND TREATMENT OF NON-MUSCLE INVASIVE BLADDER CANCER IN MODERATE AND HIGH RISK GROUPS</article-title><trans-title-group xml:lang="ru"><trans-title>ПОДДЕРЖИВАЮЩАЯ ВНУТРИПУЗЫРНАЯ ТЕРАПИЯ ВАКЦИНОЙ БЦЖ КАК СТАНДАРТ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ У БОЛЬНЫХ НЕМЫШЕЧНО-ИНВАЗИВНЫМ РАКОМ МОЧЕВОГО ПУЗЫРЯ ПРОМЕЖУТОЧНОЙ И ВЫСОКОЙ ГРУПП РИСКА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Alekseev</surname><given-names>B. Ya.</given-names></name><name xml:lang="ru"><surname>Алексеев</surname><given-names>Б. Я.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>byalekseev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Golovashchenko</surname><given-names>M. P.</given-names></name><name xml:lang="ru"><surname>Головащенко</surname><given-names>М. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>byalekseev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">P.A. Herzen Moscow Oncology Research Institute</institution></aff><aff><institution xml:lang="ru">МНИОИ им. П.А. Герцена</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-09-30" publication-format="electronic"><day>30</day><month>09</month><year>2012</year></pub-date><volume>8</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>12</fpage><lpage>17</lpage><history><date date-type="received" iso-8601-date="2014-08-05"><day>05</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-05"><day>05</day><month>08</month><year>2014</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncourology.abvpress.ru/oncur/article/view/309">https://oncourology.abvpress.ru/oncur/article/view/309</self-uri><abstract xml:lang="en"><p>Notwithstanding the fact that BCG vaccine therapy is considered to be the most effective method to treat and prevent non-muscle invasive bladder cancer recurrences, maintenance therapy is performed insufficiently often. Whether long-term courses of intravesicular BCG installations are needed to obtain optimal results remains unsolved so far.</p></abstract><trans-abstract xml:lang="ru"><p>Несмотря на то, что терапия вакциной БЦЖ считается наиболее эффективным методом лечения и профилактики рецидивов немышечно-инвазивного рака мочевого пузыря, поддерживающий режим терапии применяется недостаточно часто. До сих пор остается нерешенным вопрос: требуется ли проведение пролонгированных курсов внутрипузырных инстилляций БЦЖ с целью получения оптимальных результатов?</p></trans-abstract><kwd-group xml:lang="en"><kwd>non-muscle invasive bladder cancer</kwd><kwd>BCG</kwd><kwd>maintenance therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>немышечно-инвазивный рак мочевого пузыря</kwd><kwd>БЦЖ</kwd><kwd>поддерживающая терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Lamm D.L., Blumenstein B.A., Crissman J.D. et al. Maintenance bacillus Calmette-Guerin immunotherapy for recurrent TA, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study. J Urol 2000;163:1124−9.</mixed-citation><mixed-citation xml:lang="ru">Lamm D.L., Blumenstein B.A., Crissman J.D. et al. Maintenance bacillus Calmette-Guerin immunotherapy for recurrent TA, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study. J Urol 2000;163:1124−9.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Sylvester R.J., van der Meijden A.P., Lamm D.L. Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a combined analysis of the published results of randomized clinical trials. J Urol 2002; 168:1964−70.</mixed-citation><mixed-citation xml:lang="ru">Sylvester R.J., van der Meijden A.P., Lamm D.L. Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a combined analysis of the published results of randomized clinical trials. J Urol 2002; 168:1964−70.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Böhle A., Jocham D., Bock P.R. Intravesical bacillus Calmette-Guerin versus mitomycin C for superficial bladder cancer: a formal metaanalysis of comparative studies on recurrence and toxicity. J Urol 2003; 169:90−5.</mixed-citation><mixed-citation xml:lang="ru">Böhle A., Jocham D., Bock P.R. Intravesical bacillus Calmette-Guerin versus mitomycin C for superficial bladder cancer: a formal metaanalysis of comparative studies on recurrence and toxicity. J Urol 2003; 169:90−5.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Böhle A., Bock P.R. Intravesical bacilli Calmette-Guérin versus mitomycin C in superficial bladder cancer: formal metaanalysis of comparative studies on tumor progression. Urology 2004;63:682−6.</mixed-citation><mixed-citation xml:lang="ru">Böhle A., Bock P.R. Intravesical bacilli Calmette-Guérin versus mitomycin C in superficial bladder cancer: formal metaanalysis of comparative studies on tumor progression. Urology 2004;63:682−6.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Sylvester R.J., van der Meijden A.P., Witjes J.A. et al. Bacillus Calmette-Guerin versus chemotherapy for the intravesical treatment of patients with carcinoma in situ of the bladder: a meta-analysis of the published results of randomized clinical trials. J Urol 2005;174:86−91.</mixed-citation><mixed-citation xml:lang="ru">Sylvester R.J., van der Meijden A.P., Witjes J.A. et al. Bacillus Calmette-Guerin versus chemotherapy for the intravesical treatment of patients with carcinoma in situ of the bladder: a meta-analysis of the published results of randomized clinical trials. J Urol 2005;174:86−91.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Han R.F., Pan J.G. Can intravesical bacillus Calmette-Guerin reduce recurrence in patients with superficial bladder cancer? A metaanalysis of randomized trials. Urology 2006;67:1216−23.</mixed-citation><mixed-citation xml:lang="ru">Han R.F., Pan J.G. Can intravesical bacillus Calmette-Guerin reduce recurrence in patients with superficial bladder cancer? A metaanalysis of randomized trials. Urology 2006;67:1216−23.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Malmström P.U., Sylvester R.J., Crawford D.E. et al. An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guérin for non-muscle-invasive bladder cancer. Eur Urol 2009;56:247−56.</mixed-citation><mixed-citation xml:lang="ru">Malmström P.U., Sylvester R.J., Crawford D.E. et al. An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guérin for non-muscle-invasive bladder cancer. Eur Urol 2009;56:247−56.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Sylvester R.J., Brausi M.A., Kirkels W.J. et al. Long-term efficacy results of EORTC Genito-Urinary Group randomized phase 3 study 30911 comparing intravesical instillations of epirubicin, bacillus Calmette-Guerin, and bacillus Calmette-Guerin plus isoniazid in patients with intermediate- and high-risk stage Ta T1 urothelial carcinoma of the bladder. Eur Urol 2010;57:766−73.</mixed-citation><mixed-citation xml:lang="ru">Sylvester R.J., Brausi M.A., Kirkels W.J. et al. Long-term efficacy results of EORTC Genito-Urinary Group randomized phase 3 study 30911 comparing intravesical instillations of epirubicin, bacillus Calmette-Guerin, and bacillus Calmette-Guerin plus isoniazid in patients with intermediate- and high-risk stage Ta T1 urothelial carcinoma of the bladder. Eur Urol 2010;57:766−73.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Hinotsu S., Akaza H., Naito S. et al. Maintenance therapy with bacillus Calmette-Guerin (BCG) Connaught strain clearly prolongs recurrence-free survival following transurethral resection of bladder tumor (TURBT) for non-muscle-invasive transitional cell carcinoma of the bladder. BJU Int 2011;108(2):187−95.</mixed-citation><mixed-citation xml:lang="ru">Hinotsu S., Akaza H., Naito S. et al. Maintenance therapy with bacillus Calmette-Guerin (BCG) Connaught strain clearly prolongs recurrence-free survival following transurethral resection of bladder tumor (TURBT) for non-muscle-invasive transitional cell carcinoma of the bladder. BJU Int 2011;108(2):187−95.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Lamm D., Persad R., Colombel M., Brausi M. Maintenance Bacillus Calmette-Guerin: The standard of care for the prophylaxis and management of intermediateand high-risk non-muscle-invasive bladder cancer. Eur Urol Suppl 2010;9:715−34.</mixed-citation><mixed-citation xml:lang="ru">Lamm D., Persad R., Colombel M., Brausi M. Maintenance Bacillus Calmette-Guerin: The standard of care for the prophylaxis and management of intermediateand high-risk non-muscle-invasive bladder cancer. Eur Urol Suppl 2010;9:715−34.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Taniguchi K., Koga S., Nishikido M. et al. Systemic immune response after intravesical instillation of bacille Calmette-Guerin (BCG) for superficial bladder cancer. Clin Exp Immunol 1999;115:131−5.</mixed-citation><mixed-citation xml:lang="ru">Taniguchi K., Koga S., Nishikido M. et al. Systemic immune response after intravesical instillation of bacille Calmette-Guerin (BCG) for superficial bladder cancer. Clin Exp Immunol 1999;115:131−5.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Chen F., Zhang G., Iwamoto Y., See W.A. BCG directly induces cell cycle arrest in human transitional carcinoma cell lines as a consequence of integrin cross-linking. BMC Urol 2005;5:8.</mixed-citation><mixed-citation xml:lang="ru">Chen F., Zhang G., Iwamoto Y., See W.A. BCG directly induces cell cycle arrest in human transitional carcinoma cell lines as a consequence of integrin cross-linking. BMC Urol 2005;5:8.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. O’Donnell M.A., DeWolf W.C. BCG immunotherapy for superficial bladder cancer. New prospects for an old warhorse. Surg Oncol Clin North Amer 1995;4:189−202.</mixed-citation><mixed-citation xml:lang="ru">O’Donnell M.A., DeWolf W.C. BCG immunotherapy for superficial bladder cancer. New prospects for an old warhorse. Surg Oncol Clin North Amer 1995;4:189−202.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Prescott S., James K., Hargreave T.B. et al. Intravesical Evans strain BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall. J Urol 1992;147:1636−42.</mixed-citation><mixed-citation xml:lang="ru">Prescott S., James K., Hargreave T.B. et al. Intravesical Evans strain BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall. J Urol 1992;147:1636−42.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Cookson M.S., Herr H.W., Zhang Z.F. et al. The treated natural history of high risk superficial bladder cancer: 15-year outcome. J Urol 1997;158:62−7.</mixed-citation><mixed-citation xml:lang="ru">Cookson M.S., Herr H.W., Zhang Z.F. et al. The treated natural history of high risk superficial bladder cancer: 15-year outcome. J Urol 1997;158:62−7.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Reichert D.F., Lamm D.L. Long term protection in bladder cancer following intralesional immunotherapy. J Urol 1984; 132:570−3.</mixed-citation><mixed-citation xml:lang="ru">Reichert D.F., Lamm D.L. Long term protection in bladder cancer following intralesional immunotherapy. J Urol 1984; 132:570−3.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Shelley M.D., Mason M.D., Kynaston H. Intravesical therapy for superficial bladder cancer: a systematic review of randomized trials and meta-analyses. Cancer Treat Rev 2010;36:195−205.</mixed-citation><mixed-citation xml:lang="ru">Shelley M.D., Mason M.D., Kynaston H. Intravesical therapy for superficial bladder cancer: a systematic review of randomized trials and meta-analyses. Cancer Treat Rev 2010;36:195−205.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Bladder cancer: guideline for the management of non-muscle invasive bladder cancer (stages Ta,T1, and Tis): 2007 update. American Urological Association Web site. http://www.auanet.org/content/guidelinesand-quality-care/clinical-guidelines.cfm?sub=bc&amp;CFID=673377&amp;CFTOKEN=95927192&amp;jsessionid=843082c98dcd9c03ed6c6863583e7735217f.</mixed-citation><mixed-citation xml:lang="ru">Bladder cancer: guideline for the management of non-muscle invasive bladder cancer (stages Ta,T1, and Tis): 2007 update. American Urological Association Web site. http://www.auanet.org/content/guidelinesand-quality-care/clinical-guidelines.cfm?sub=bc&amp;CFID=673377&amp;CFTOKEN=95927192&amp;jsessionid=843082c98dcd9c03ed6c6863583e7735217f.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Babjuk M., Oosterlinck W., Sylvester R. et al. Guidelines on Ta, T1(non-muscle invasive) bladder cancer. European Association of Urology Web site. http://www.uroweb.org/gls/ pdf/TaT1%20(nonmuscle%20invasive)%20bladder%20cancer%202010.pdf.Updated 2009.</mixed-citation><mixed-citation xml:lang="ru">Babjuk M., Oosterlinck W., Sylvester R. et al. Guidelines on Ta, T1(non-muscle invasive) bladder cancer. European Association of Urology Web site. http://www.uroweb.org/gls/ pdf/TaT1%20(nonmuscle%20invasive)%20bladder%20cancer%202010.pdf.Updated 2009.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Lamm D., Colombel M., Persad R. et al. Clinical practice recommendations for the management of non-muscle invasive bladder cancer. Eur Urol Suppl 2008;7:651−66.</mixed-citation><mixed-citation xml:lang="ru">Lamm D., Colombel M., Persad R. et al. Clinical practice recommendations for the management of non-muscle invasive bladder cancer. Eur Urol Suppl 2008;7:651−66.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Soloway M.S., editor. International consultation on bladder tumours. Urology 2005;66 (Suppl 1):1−125.</mixed-citation><mixed-citation xml:lang="ru">Soloway M.S., editor. International consultation on bladder tumours. Urology 2005;66 (Suppl 1):1−125.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Martinez-Pineiro J.A., Flores N., Isorna S. et al., for CUETO (Club Urologico Espanol de Tratamiento Oncologico). Long-term follow-up of a randomized prospective trial comparing a standard 81 mg dose of intravesical bacille Calmette-Guerin with a reduced dose of 27 mg in superficial bladder cancer. BJU Int 2002;89:671−80.</mixed-citation><mixed-citation xml:lang="ru">Martinez-Pineiro J.A., Flores N., Isorna S. et al., for CUETO (Club Urologico Espanol de Tratamiento Oncologico). Long-term follow-up of a randomized prospective trial comparing a standard 81 mg dose of intravesical bacille Calmette-Guerin with a reduced dose of 27 mg in superficial bladder cancer. BJU Int 2002;89:671−80.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Martinez-Pineiro J.A., Martinez-Pineiro L., Solsona E. et al., for CUETO (Club Urologico Espanol de Tratamiento Oncologico). Has a 3-fold decreased dose of bacillus Calmette-Guerin the same efficacy against recurrences and progression of T1G3 and Tis bladder tumors than the standard dose? Results of a prospective randomized trial. J Urol 2005; 174:1242−7.</mixed-citation><mixed-citation xml:lang="ru">Martinez-Pineiro J.A., Martinez-Pineiro L., Solsona E. et al., for CUETO (Club Urologico Espanol de Tratamiento Oncologico). Has a 3-fold decreased dose of bacillus Calmette-Guerin the same efficacy against recurrences and progression of T1G3 and Tis bladder tumors than the standard dose? Results of a prospective randomized trial. J Urol 2005; 174:1242−7.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Lamm D., Böhle A., Palou J. et al. Re: Per-Uno Malmström, Richard J. Sylvester, David E. Crawford, et al. An individual patient data metaanalysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guerin for non-muscleinvasive bladder cancer. Eur Urol 2010; 57:p7−9.</mixed-citation><mixed-citation xml:lang="ru">Lamm D., Böhle A., Palou J. et al. Re: Per-Uno Malmström, Richard J. Sylvester, David E. Crawford, et al. An individual patient data metaanalysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guerin for non-muscleinvasive bladder cancer. Eur Urol 2010; 57:p7−9.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Huncharek M., Kupelnick B. Impact of intravesical chemotherapy versus BCG immunotherapy on recurrence of superficial transitional cell carcinoma of the bladder: meta-analytic reevaluation. Am J Clin Oncol 2003;26:402−7.</mixed-citation><mixed-citation xml:lang="ru">Huncharek M., Kupelnick B. Impact of intravesical chemotherapy versus BCG immunotherapy on recurrence of superficial transitional cell carcinoma of the bladder: meta-analytic reevaluation. Am J Clin Oncol 2003;26:402−7.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Huncharek M., Kupelnick B. The influence of intravesical therapy on progression of superficial transitional cell carcinoma of the bladder: a meta-analytic comparison of chemotherapy versus bacilli Calmette-Guerin immunotherapy. Am J Clin Oncol 2004;27:522−8.</mixed-citation><mixed-citation xml:lang="ru">Huncharek M., Kupelnick B. The influence of intravesical therapy on progression of superficial transitional cell carcinoma of the bladder: a meta-analytic comparison of chemotherapy versus bacilli Calmette-Guerin immunotherapy. Am J Clin Oncol 2004;27:522−8.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Järvinen R., Kaasinen E., Sankila A. et al. Long-term efficacy of maintenance bacillus Calmette-Guérin versus maintenance mitomycin C instillation therapy in frequently recurrent Ta, T1 tumours without carcinoma in situ: a subgroup analysis of the prospective, randomised FinnBladder I study with a 20-year follow-up. Eur Urol 2009; 56(2):260−5.</mixed-citation><mixed-citation xml:lang="ru">Järvinen R., Kaasinen E., Sankila A. et al. Long-term efficacy of maintenance bacillus Calmette-Guérin versus maintenance mitomycin C instillation therapy in frequently recurrent Ta, T1 tumours without carcinoma in situ: a subgroup analysis of the prospective, randomised FinnBladder I study with a 20-year follow-up. Eur Urol 2009; 56(2):260−5.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Witjes J.A., Palou J., Soloway M. et al. Clinical practice recommendations for the prevention and management of intravesical therapy associated adverse events. Eur Urol Suppl 2008;7:667−74.</mixed-citation><mixed-citation xml:lang="ru">Witjes J.A., Palou J., Soloway M. et al. Clinical practice recommendations for the prevention and management of intravesical therapy associated adverse events. Eur Urol Suppl 2008;7:667−74.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Böhle A., Balck F., von Wietersheim J., Jocham D. The quality of life during intravesical bacillus Calmette-Guérin therapy. J Urol 1996;155:1221−6.</mixed-citation><mixed-citation xml:lang="ru">Böhle A., Balck F., von Wietersheim J., Jocham D. The quality of life during intravesical bacillus Calmette-Guérin therapy. J Urol 1996;155:1221−6.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Lundholm C., Norlen B.J., Ekman P. et al. A randomized prospective study comparing long-term intravesical instillations of mitomycin C and bacillus Calmette-Guérin in patients with superficial bladder carcinoma. J Urol 1996;156:372−6.</mixed-citation><mixed-citation xml:lang="ru">Lundholm C., Norlen B.J., Ekman P. et al. A randomized prospective study comparing long-term intravesical instillations of mitomycin C and bacillus Calmette-Guérin in patients with superficial bladder carcinoma. J Urol 1996;156:372−6.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Krege S., Giani G., Meyer R. et al. A randomized multicenter trial of adjuvant therapy in superficial bladder cancer: transurethral resection only versus transurethral resection plus mitomycin C versus transurethral resection plus bacillus Calmette-Guérin. Participating Clinics. J Urol 1996;156:962−6.</mixed-citation><mixed-citation xml:lang="ru">Krege S., Giani G., Meyer R. et al. A randomized multicenter trial of adjuvant therapy in superficial bladder cancer: transurethral resection only versus transurethral resection plus mitomycin C versus transurethral resection plus bacillus Calmette-Guérin. Participating Clinics. J Urol 1996;156:962−6.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Lamm D.L. Complications of bacillus Calmette-Guérin immunotherapy. Urol Clin North Am 1992;19:565−72.</mixed-citation><mixed-citation xml:lang="ru">Lamm D.L. Complications of bacillus Calmette-Guérin immunotherapy. Urol Clin North Am 1992;19:565−72.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Falkensammer C., Gozzi C., Hager M. et al. Late occurrence of bilateral tuberculouslike epididymo-orchitis after intravescical bacille Calmette-Guerin therapy for superficial bladder carcinoma. Urology 2005;65:175.</mixed-citation><mixed-citation xml:lang="ru">Falkensammer C., Gozzi C., Hager M. et al. Late occurrence of bilateral tuberculouslike epididymo-orchitis after intravescical bacille Calmette-Guerin therapy for superficial bladder carcinoma. Urology 2005;65:175.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Steg A., Leleu C., Debre B. et al. Systemic bacillus Calmette-Guérin infection: ‘BCGitis’ in patients treated by intravescical bacillus Calmette-Guérin therapy for bladder cancer. Eur Urol 1989;16:161−4.</mixed-citation><mixed-citation xml:lang="ru">Steg A., Leleu C., Debre B. et al. Systemic bacillus Calmette-Guérin infection: ‘BCGitis’ in patients treated by intravescical bacillus Calmette-Guérin therapy for bladder cancer. Eur Urol 1989;16:161−4.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Witjes J.A., Palou J., Soloway M. et al. Clinical practice recommendations for the prevention and management of intravesical therapy associated adverse events. Eur Urol Suppl 2008;7:667−74.</mixed-citation><mixed-citation xml:lang="ru">Witjes J.A., Palou J., Soloway M. et al. Clinical practice recommendations for the prevention and management of intravesical therapy associated adverse events. Eur Urol Suppl 2008;7:667−74.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Rischmann P. Improving compliance of BCG immunotherapy: practical approaches to managing side-effects. Eur Urol Suppl 2006;5:660−2.</mixed-citation><mixed-citation xml:lang="ru">Rischmann P. Improving compliance of BCG immunotherapy: practical approaches to managing side-effects. Eur Urol Suppl 2006;5:660−2.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Picard A., Champetier D., Perrin P. et al. Discontinuance of BCG instillation for non-muscle invasive bladder cancer: prognostic impact on recurrence. Poster presented at: European Association of Urology 25th Annual Congress; April 16−20, 2010; Barcelona, Spain.</mixed-citation><mixed-citation xml:lang="ru">Picard A., Champetier D., Perrin P. et al. Discontinuance of BCG instillation for non-muscle invasive bladder cancer: prognostic impact on recurrence. Poster presented at: European Association of Urology 25th Annual Congress; April 16−20, 2010; Barcelona, Spain.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Van der Meijden A.P.M., Sylvester R.J., Oosterlinck W. et al. for the EORTC Genito-Urinary Tract Cancer Group. Maintenance bacillus Calmette-Guérin for Ta T1 bladder tumors is not associated with increased toxicity: results from a European Organisation for Research and Treatment of Cancer Genito-Urinary Group phase III trial. Eur Urol 2003;44:429−34.</mixed-citation><mixed-citation xml:lang="ru">Van der Meijden A.P.M., Sylvester R.J., Oosterlinck W. et al. for the EORTC Genito-Urinary Tract Cancer Group. Maintenance bacillus Calmette-Guérin for Ta T1 bladder tumors is not associated with increased toxicity: results from a European Organisation for Research and Treatment of Cancer Genito-Urinary Group phase III trial. Eur Urol 2003;44:429−34.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">39. Decobert M., LaRue H., Harel F. et al. Maintenance bacillus Calmette-Guérin in high-risk non-muscle invasive bladder cancer: how much is enough? Cancer 2008; 113:710−6.</mixed-citation><mixed-citation xml:lang="ru">Decobert M., LaRue H., Harel F. et al. Maintenance bacillus Calmette-Guérin in high-risk non-muscle invasive bladder cancer: how much is enough? Cancer 2008; 113:710−6.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">40. Colombel M., Saint F., Chopin D. et al. The effect of ofloxacin on bacillus Calmette-Guérin induced toxicity in patients with superficial bladder cancer: results of a randomized, prospective, double-blind, placebo controlled, multicenter study. J Urol 2006; 176:935−9.</mixed-citation><mixed-citation xml:lang="ru">Colombel M., Saint F., Chopin D. et al. The effect of ofloxacin on bacillus Calmette-Guérin induced toxicity in patients with superficial bladder cancer: results of a randomized, prospective, double-blind, placebo controlled, multicenter study. J Urol 2006; 176:935−9.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">41. Buckley R., Rischmann P., Colombel M. et al. Prophylactic ofloxacin to improve tolerance of BCG instillations: two-year results of a prospective double-blind placebocontrolled study in patients with bladder cancer [Abstract PD-11.12]. Poster presented at: Societe Internationale d’Urologie (SIU) 28th Congress; November 12−16, 2006; Cape Town, South Africa.</mixed-citation><mixed-citation xml:lang="ru">Buckley R., Rischmann P., Colombel M. et al. Prophylactic ofloxacin to improve tolerance of BCG instillations: two-year results of a prospective double-blind placebocontrolled study in patients with bladder cancer [Abstract PD-11.12]. Poster presented at: Societe Internationale d’Urologie (SIU) 28th Congress; November 12−16, 2006; Cape Town, South Africa.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">42. Nieder A.M., Sved P.D., Stein J.P. et al. Cystoprostatectomy and orthotopic ileal neobladder reconstruction for management of bacille Calmette-Guérin-induced bladder contractures. Urology 2005;65:909−12.</mixed-citation><mixed-citation xml:lang="ru">Nieder A.M., Sved P.D., Stein J.P. et al. Cystoprostatectomy and orthotopic ileal neobladder reconstruction for management of bacille Calmette-Guérin-induced bladder contractures. Urology 2005;65:909−12.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
