Cancer UrologyCancer UrologyОнкоурология1726-97761996-1812Publishing House ABV Press29210.17650/1726-9776-2009-5-4-25-36DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ МОЧЕПОЛОВОЙ СИСТЕМЫTHE SIDE EFFECTS OF SORAFENIB, SUNITINIB, AND TEMSIROLIMUS AND THEIR THERAPY IN PATIENTS WITH METASTATIC RENAL-CELL CARCINOMAПОБОЧНЫЕ ЭФФЕКТЫ СОРАФЕНИБА, СУНИТИНИБА И ТЕМСИРОЛИМУСА И ИХ ЛЕЧЕНИЕ У БОЛЬНЫХ МЕТАСТАТИЧЕСКИМ ПОЧЕЧНО-КЛЕТОЧНЫМ РАКОМBhojaniN.
Canada
JeldresC.
Canada
PatardJ.-J.
France
PerrotteP.
Canada
SuardiN.
Italy
HuttererG.
Austria
PatenaudeF.
Canada
OudardS.
France
KarakiewiczP. I.
Canada
Cancer Prognostics and Health Outcomes Unit, University of Montreal2Department of Urology, University of Montreal Health Center (CHUM), QC2Department of Urology, University of MontrealHealth Center (CHUM), QCDepartment of Urology, Rennes 1 University HospitalDepartment of Urology, Rennes 1 University HospitaDepartment of Urology, University of Montreal Health Center (CHUM), QCCancer Prognostics and Health Outcomes Unit, University of MontrealDepartment of Urology, Vita-Salute University San Raff aele, MilanDepartment of Urology, Vita-Salute University San Raff aele, MilanCancer Prognostics and Health Outcomes Unit, University of MontrealDepartment of Urology, Graz Medical UniversityCancer Prevention Centre, McGill University, Montreal, QCMedical Oncology Department, Gorges Pompidou European Hospital, Paris301220095425360508201405082014https://oncourology.abvpress.ru/oncur/article/view/292

Objective: to provide a systematic review of the adverse reactions of sorafenib, sunitinib, and temsirolimus and to outline actions for their prevention and correction.

Materials and methods. To provide a description of the main methods to decrease the toxicity of these drugs, the authors made a systemat- ic review of their adverse reactions, by using the publications available in the PubMed database, monographs on the medicines, and instruc- tions for their medical use.

 Results. The frequency of their adverse reactions varied from < 1 to 72%. Grades III—IV side effects are noted more rarely; their incidence is < 1 to 13% for sorafenib, < 1 to 16% for sunitinib, and 1 to 20% for temsirolimus. Sinitinib causes most grades III—IV adverse reactions and sofafenib does the least. However, close comparative studies of the safety of these kinase inhibitors are still lacking. Virtually all side effects can be effectively prevented and treated.  

Conclusion. The prevention, timely recognition, and treatment of the adverse reactions of these agents are of great importance, which allows avoidance of the unneeded dosage reduction that may result in worse therapeutic efficiency.   

Цель исследования — представить систематический обзор побочных эффектов сорафениба, сунитиниба и темсиролимуса, а также в общих чертах описать меры по их предупреждению и коррекции.

 Материалы и методы. Для того чтобы представить описание основных методов, направленных на снижение токсичности этих препаратов, нами проведен систематический обзор побочных эффектов на основе публикаций в базе данных PubMed, монографий по лекарственным препаратам и инструкций по их медицинскому применению.

Результаты. Частота развития побочных эффектов варьирует от < 1 до 72%. Побочные эффекты III—IV степени отмечаются реже, частота их возникновения от < 1 до 13% для сорафениба, от < 1 до 16% — для сунитиниба и от 1 до 20% — для темсиролимуса. Сунитиниб вызывает наибольшее количество побочных эффектов III—IV степени, а сорафениб — наименьшее. Однако все еще отсутствуют тщательные сравнительные клинические исследования безопасности этих ингибиторов киназ. Практически все побочные эффекты можно эффективно предупреждать и лечить.

Заключение. Большое значение имеют профилактика, своевременное распознавание и лечение побочных эффектов этих препаратов, что позволяет избежать ненужного снижения дозы, грозящего ослаблением эффективности лечения.

 

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